PPT-Alexander Conway Diuretics, Antiemetics and Adverse drug reactions

15032020 1 LO please insert relevant Learning objective reference here 2 DIURETICS 3 Learning Objectives for Diuretics Renal physiology explain the physiology of the renal system and how drugs impact ionic composition. Zarif Jabbar-Lopez, MBBS, MPH. FY2, East of England Deanery. Visiting Research Fellow, Uppsala Monitoring Centre. Disclosure. No conflicts of interest. The . research leading to these results was conducted as part of the PROTECT consortium (. 41. Diuretics. Anatomy and Physiology. Anatomy. Basic functional unit of the kidney: nephron. Four functionally distinct regions. Glomerulus. Proximal convoluted tubule. Loop of Henle. Distal convoluted tubule. Alexander the Great was a young general who amassed the largest empire of the ancient world in just thirteen years. . His career was brief because he died a young man, . but Alexander’s . legacy was a . www.dentalelle.com. Pharmacology . ADVERSE REACTIONS. CHAPTER THREE. OBJECTIVES. Define and explain . the adverse reactions to drugs.. Explain the different types of adverse reactions that can occur such as . pg. 93 - 122. Gastrointestinal Drugs. Dr. . Dipa. . Brahmbhatt. VMD . MpH. , MS. dbrahmbh@yahoo.com. OBJECTIVES. Basic physiology that controls the GI tract. Mechanism of emesis and . antiemetics. Key questions. How had Alexander II (1855-1881) brought change to Russia?. What factors brought change in Russia in the period 1881-1924?. What problems did Alexander III face when he became Tsar?. How did Alexander III deal with threats to Russian autocracy?. November 2015. Adverse Drug reactions – why do you need to know about this?. Adverse Drug Reactions (ADRs)….. Cause 7% of hospital admissions. . Occur in 10-20% of hospital patients . Are experienced by 40% of patients in the community . Adverse drug reaction. . Sheena . Helyer. 1.2013. Pictures provided by cadista.com . What is an adverse drug reaction?. An adverse drug reaction (ADR) is an unwanted or harmful reaction experienced following the administration of a drug or combination of drugs.. Revised 2015 Evaluator: Name:Position:Date: PLANNING AND PREPARATION Component 1a: Demonstrating Knowledge of Content and Pedagogy1a.1Knowledge of content and the structure of the discipline1a.2Knowle Background. Primary effect of diuretics is to increase solute excretion, mainly as NaCl. Certain disease states may cause blood volume to increase outside of narrowly defined limits. Hypertension. Congestive heart failure. . Most diuretic agents are inhibitors of renal ion transporters that decrease the . reabsorption. of Na+ at different sites in the . nephron. . . As a result, Na+ and other ions, such as . Cl. −, enter the urine in greater than normal amounts along with water, which is carried passively to maintain osmotic equilibrium.. The . risk for development of a drug eruption is related to the following factors: age, gender, dose, and the nature of the medication itself. . Females . are . 1.3-1.5 . times more likely to develop drug eruptions, except in children under the age of 3 where boys are more likely to be affected. . diuresis. ). and sodium excretion (. natriuresis. ). RENAL TRANSPORT MECHANISMS . The kidney filters plasma water and solutes at the . glomerulus. at a very high rate (180 L/day) and must recover a significant percentage of most of these substances before excretion in the urine.. . Any noxious change which is . Suspected to be due to a drug. At. doses normally . used in man. May requires treatment or decrease in dose or . Caution in the future use of the same drug. ADVERSE DRUG EVENT (ADE.