PDF-Genetics DNA and HeredityThe Basics

Francis Collins What Does DNA Look LikeATGCEvery cell in our body has the same DNA133Eye cellLung cellToe cellKaryotypeHow much DNA is in one cellGenome 46 chromosomes Genome approx 3 billion base. DNA: Picture 51. http://info.bio.cmu.edu/courses/03231/ProtStruc/ProtStruc.htm. B-DNA: The advent of modeling. http://molvis.sdsc.edu/pdb/dna_b_form.pdb. 46 Å. . 12 base sequence. (1953-2003). DNA: Size, Shape & Self Assembly. People have known about inheritance for a long time.. --children resemble their parents. --domestication of animals and plants, selective breeding for good characteristics. --Sumerian horse breeding records. From classical genetics to the personal human genome. Classical Genetics:. Gregor. Mendel (1860). Discovered the classical laws of inheritance through his work with pea plants. Mendel’s work . remained unknown. Next Generation Sequencing:. A technical perspective. Bristol Genetics Laboratory. Joanne Davies. Genetic Technologist. Objectives. Summarise the NGS assays currently available at BGL. Look at the general challenges with NGS assays. A. Structure of DNA. 1. discovered by James Watson and Francis Crick in 1953. 2. stores genetic information for the production of proteins. 3. composed of nucleotides. A) a nucleotide is composed of a nitrogenous base, sugar, and phosphate. Next Generation Sequencing:. A technical perspective. Bristol Genetics Laboratory. Joanne Davies. Genetic Technologist. Objectives. Summarise the NGS assays currently available at BGL. Look at the general challenges with NGS assays. 7. Lactose digestions in . E. coli. begins with its hydrolysis by the enzyme . -. galactosidase. , . lacZ. , is part of a . coordinatley. regulated operon containing the genes required for lactose utilization. Which of the following figures correctly depicts the interactions at the . Genetics and Behavior. Behavior Geneticists. study our differences and weigh the relative effects of heredity and environment.. Chromosomes, Genes, and DNA. Chromosomes. . (46 in each sell) containing .  . 5 marks. Question 1 - Answers. U. =Unique sequences; . H. = Highly repetitive sequences. U: occur once in genome; H: occur many times;. U: long base sequences; H: short sequences/5–300 bases;. Identify which of the offspring in dihybrid crosses are recombinants.. Question 1 - Answers. Question 2. Describe the methods and aims of DNA profiling..  . 8 marks. Question 2 - Answers. Award 5 max for methods.. Lectures. . – . 17x2 (Med); . 17x1. (. Stom. ). ;. Seminars. – . 17x3 (Med); . 17x2. (. Stom. ). ;. 3 . concluding . tests. (. tests. + . practical part. ). Final . examination . (. tests. + . Upgraded Lecture Note Series Jimma Universit y MOLECULAR BIOLOGY AND APPLIED GENETICS Lecture Note Series Democratic Republic of Ethiopia Ministry of Education and Ministry of Health The problem fa 1 Cells and DNA 1 What is a cell? Cells are the basic building blocks of all living things. The human body is composed of trillions of cells. They provide structure for the body, take in nutrient Medical genetics involves any application of genetics to medical practice. It thus includes: . studies of the inheritance of diseases in families. the mapping of disease genes to specific locations on chromosomes, .