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HISTOLOGY OF PANCREAS PANCREAS HISTOLOGY OF PANCREAS PANCREAS

HISTOLOGY OF PANCREAS PANCREAS - PowerPoint Presentation

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Uploaded On 2022-08-02

HISTOLOGY OF PANCREAS PANCREAS - PPT Presentation

Has exocrine amp endocrine functions Parts Capsule Septa lobules Secretions Enzymes Hormones EXOCRINE PANCREAS COMPOUND ACCINAR GLAND Pear shaped accini 58 pyramidal cells Reticular fibers support accini ID: 932739

pancreas cells exocrine islets cells pancreas islets exocrine ducts accini supply fibers pancreatic application medical amp insulin rer cords

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Presentation Transcript

Slide1

HISTOLOGY OF PANCREAS

Slide2

PANCREAS

Has exocrine & endocrine functions

Parts

Capsule

Septa – lobules

Secretions:

Enzymes

Hormones

Slide3

EXOCRINE PANCREAS

COMPOUND ACCINAR GLAND

Pear shaped accini

5-8 pyramidal cells

Reticular fibers support accini

Inter- lobular CT contains:

Blood vesselsNerves Lymphatic

Slide4

EXOCRINE PANCREAS

ACCINI

Cells have spherical basal nucleus

Basal cytoplasm basophilic –RER

mitochondria

Golgi apparatus

Apical zymogen granules – maximum in fasted personCentroacinar cells

Slide5

Slide6

EXOCRINE PANCREAS

DUCTS

Intercalated ducts

NO

striated ducts

Large intralobular ducts –high cuboidal epithelium

Interlobular ducts – columnar epitheliumLarger ducts

Main duct

Slide7

SECRETIONS OF EXOCRINE PANCREAS

Proteases (trypsinogen & chymotrypsinogen etc.)

Amylase

Lipase

Nucleases (DNAase & RNAase)

Slide8

MEDICAL APPLICATION

ACUTE NECROTIZING PANCREATITIS

Proenzyme activated

Digest pancreatic tissue

Causes:

Alcoholism

Gall stonesTrauma Drugs

Slide9

MEDICAL APPLICATION

Extreme malnutrition e.g. kwashiorkor

Atrophy of pancreatic

acinar

cells

Loss of RER

Digestive enzyme production hindered

Slide10

ENDOCRINE PANCREAS (ISLETS)

Embedded within accini

100-200µm diameter

> 1 million islets

Abundant in tail

Slide11

ISLETS OF LANGERHANS

Reticular fibers surround each islet

Small polygonal cells

Cells lightly stained

Arranged in anastomosing cords

Fenestrated capillaries between cords

Autonomic fibers

Slide12

ISLETS OF LANGERHANS

CELLS OF ISLETS

A /

α

cells- glucagon, at periphery

B /

β cells- insulin, at center-numerousD /

δ

cells-

somatostatin

, scattered

F /PP cells- pancreatic polypeptide

Enterochromaffin

cells-

motilin,secretin

,

substane

-P

Slide13

BLOOD SUPPLY

Rich arterial supply

Major BV run in interlobular CT

Intralobular BV

Arterioles pass to islets

Extensive capillary network

First supply peripheral cellsBlood from islets pass to supply exocrine tissueHormones effect acinar function

Slide14

Slide15

COMPARISON

PANCREAS

PAROTID GLAND

Slide16

MEDICAL APPLICATION

INSULIN DEPENDENT / TYPE I DIABETES (juvenile)

Autoimmune disease

Partial or total destruction of

β

cells

Lack of insulinINSULIN INDEPENDENT DIABETES / TYPE IIAdult onsetAssociated with obesityFailure of cell to respond to insulinTUMOURS OF ISLETSMay secrete anyone of the hormonesMay secrete more than one hormone