NK cells are stimulated by Yac1 cells due to their lack of MHC I expression NK cells lyse immature dendritic cells with perforin Therefore only mature dendritic cells survive Mature dendritic cells then promote a Th1 response ID: 931723
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NK Cells Fighting Cancer
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NK cells are stimulated by Yac-1 cells due to their lack of MHC I expression.
NK cells lyse immature dendritic cells with
perforin
. Therefore, only mature dendritic cells survive. Mature dendritic cells then promote a Th1 response.Mice were protected from injected carcinomas if they were treated with Yac-1 cells first, meaning NK cells could potentially help fight back against cancer.Adapted from: Morandi, et al. 2012. PLoS One. 7: e39170.
Yac-1 Cell
NK Cell
Immature Dendritic Cell
Lysis
Mature Dendritic Cell
Th1 Cell
Perforin
Tumor Cell Destruction
IFN
γ
TNF
α
, Proinflammatory Cytokines