John MD MBA Case of a new onset Bipolar Disorder A 60yearold righthanded previously successful and psychiatrically healthy businessman was brought by his family to a university hospital neuropsychiatry service for consultation regarding behavioral and personality changes ID: 933862
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Slide1
Mental health and Aging
Vineeth
John MD MBA
Slide2Case of a new onset Bipolar Disorder
A 60-year-old, right-handed, previously successful and psychiatrically healthy businessman was brought by his family to a university hospital neuropsychiatry service for consultation regarding behavioral and personality changes.
When he was age 55 years, his customarily excellent financial and social judgment began to decline. Over the next 4 years, his attention to personal hygiene deteriorated, his business decisions became financially and ethically unsound, his range of social interests narrowed dramatically, and he developed an insatiable "sweet tooth."
One month before the neuropsychiatric consultation, he had received a diagnosis of late-onset bipolar disorder and had begun treatment with lithium carbonate. When his serum lithium level reached the therapeutic range, his cognitive, behavioral, and motor function declined precipitously, prompting the consultation for a second diagnostic opinion. Is this patient’s presentation consistent with late-onset bipolar disorder? What assessments are needed to clarify his diagnosis
Slide3Case of a new onset Bipolar Disorder
In the year preceding the consultation, his ability to maintain sleep diminished, he began spending money recklessly and impulsively and became unable to appreciate the feelings and concerns of others, and his speech and behavior took on a
perseverative
quality. Concurrently, he developed unprovoked, brief, frequent, and excessively intense episodes of tearfulness and laughing. These episodes lasted minutes at most, after which he would return to his usual
euthymic
emotional state.
Slide4Case of a new onset Bipolar Disorder
One month before the neuropsychiatric consultation, he had received a diagnosis of late-onset bipolar disorder and had begun treatment with lithium carbonate. When his serum lithium level reached the therapeutic range, his cognitive, behavioral, and motor function declined precipitously, prompting the consultation for a second diagnostic opinion
.
Slide5Slide6Late onset psychosis
Psychosis of Alzheimer's disease
Late onset Schizophrenia
Late life delusional disorder
Psychotic disorders secondary to General Medical Conditions
Slide7Psychosis in AD
Increased risk of agitation
Increase in aggression
Poor self care
Disruptive behavior
Wandering
High rate of institutionalization
Slide8Psychosis in AD
Between 30 to 50 % of AD patients have psychotic symptoms
Psychotic symptoms are more prevalent as the disease progresses but are more common in the middle stages.
Visual hallucinations are more common than auditory hallucinations.
Slide9Common themes of delusions in AD
Stealing
Stranger in the house
Spying
Impersonating the spouse or loved one
Slide10Psychosis in other dementias
Dementia of
Lewy
bodies -VH and Delusions
Parkinson's Disease - Delusions and hallucinations
Vascular Dementia
Slide11Treatment of Psychotic Symptoms in Dementia
Low dose antipsychotics are the norm.
Careful balancing of the risks and benefits need to be performed.
Slide12Delusions in Dementia
Hallucinations in Dementia
Agitation in Dementia
Depressed Mood in Dementia
Devanand
et al. Archives of General Psychiatry 1997;54(3) 257-63
Slide13Agitation in Dementia
Treat reversible causes of agitation-UTI, medications, alterations in renal functions, pain and discomfort
Behavioral Interventions
Antipsychotic medications
Anticonvulsants
Acetyl Cholinesterase Inhibitors/
Memantine
SSRIs and antidepressant therapy
Slide14Factors affecting Psychosocial interventions
Individual biography
Individual’s personality
Coexisting physical and mental health problems
Person’s social relationships
Physical environment in which the person is living
Community and cultural understandings of tolerance for confusion and frailty
Extent and location of the disease
Slide15Psychotherapeutic Interventions
Behavior management training
Caregiver training
Scheduled toileting
Reminiscence therapy
Validation therapy
Supportive therapy
Reality orientation
Art therapy
Slide16Slide17Slide18Late onset Schizophrenia
Schizophrenia is characterized by it's onset in youth and subsequent deterioration of functionality.
Schizophrenia after 45 years of age was considered late onset by APA DSM III R, 1987. International consensus panel chose 40 years as the cut off point.
No such distinction is elaborated in DSM IV TR version.
Slide19What are the distinct features of late onset schizophrenia
?
Lack of negative symptoms
Lack of thought disorder
More paranoid schizophrenia subtype
Presence of the features of
neurodegeneration
–CVAs.
More in women than in men
Patients who develop late onset schizophrenia were also noted to have sensory deficits - visual and hearing
Slide20Differential diagnosis of late onset schizophrenia
Psychotic disorders secondary to general medical conditions
Psychotic symptoms which might be part of delirium
Early onset schizophrenia undetected
Mood disorders with psychotic features
Delusional disorders
Slide21Slide22Slide23PDGMC vs
Schizophrenia
INDICATORS
PDGMC
SCHIZOPHRENIA
ONSET
SUDDEN
GRADUAL
DRUG/ALCOHOL HISTORY
TEMPORALLY RELATED
COMORBIDITY
MEDICAL HISTORY
COMMON
INFREQUENT
CONCOMITANT MEDS
FREQUENT
INFREQUENT
FAMILY
HISTORY
NOT FOR PSYCHOSIS
+/-
HALLUCINATIONS
MULTIMODAL
AUDITORY USUALLY
Slide24Treatment of late onset schizophrenia
Atypical antipsychotics
Psychosocial treatments-social skills, CBT
Family interventions for relapse prevention
Slide25Aging and Early onset Schizophrenia
Around 30% could show evidence for improvement and remission.
Cognitive deterioration is reasonably steady and do deteriorate significantly
Slide26John Nash Jr
- “ A beautiful mind”
John Nash, Jr
- In his own words
“But after my return to the dream-like delusional hypotheses in the later 60's I became a person of
delusionally
influenced thinking but of relatively moderate behavior and thus tended to avoid hospitalization and the direct attention of psychiatrists.
Thus further time passed. Then gradually I began to intellectually reject some of the
delusionally
influenced lines of thinking which had been characteristic of my orientation. This began, most recognizably, with the rejection of politically-oriented thinking as essentially a hopeless waste of intellectual effort.”
Slide28Psychotic disorders due to general medical conditions in the elderly
Stroke
Parkinson's disease
Epilepsy
Herpes Encephalitis
Thyroid and adrenal disorders
Folate
, B
12
deficiencies
Systemic lupus
erythematosus
Alcoholic
hallucinosis
Slide29Medications causing psychotic symptoms
Levadopa
Bromicriptine
Amantadine
Isoniazid
Corticosteroids
Amphetamines
Methylphenidate
Lidocaine
Cimetidine
Slide30Mood disorders secondary to general medical conditions
Rate of depression in the medical population is 12 to 20%.
Many physical illnesses and medications can cause symptoms mimicking depression.
Slide31Common medical conditions causing depression
Strokes
Parkinson's Disease
Hypothyroidism
Addison's Disease
Occult carcinoma of the Pancreas
Collagen vascular disease
Multiple sclerosis
Slide32Most common medications causing depression
Antihypertensives
-
reserpine
and methyl
dopa
Steroids
Slide33Secondary Mania
Stroke
Right hemisphere cerebral
neoplasms
Multiple sclerosis
Encephalitis
Syphilis
Head injury
Uremia
Slide34Secondary Mania
Corticosteroids
Thyroxin
Levodopa
Bromocriptine
Amphetamines
Cimetidine
Slide35Dimensions of Grief and Bereavement
Emotional and cognitive experiences
Coping strategies
Continuing relationship with the deceased
Health, occupational and social functioning
Relationships
Social identity and Self esteem
Slide36Complications of Grief and Bereavement
Morbidity
Increased somatic complaints
Worsening of pre existing illnesses
Increased use of medical services
Mortality
Widowers: highest risk in the first six months
Widows: period of risk delayed by 1or 2 years.
Slide37Psychiatric complications of grief
Substance use
Anxiety symptoms
PTSD
Depression
Slide38Unnatural sudden unexpected death
Preexisting mood disorder
Early, intense depressive reaction after the loss
Poor physical health
Increased alcohol consumption
Family history of major depression
Poor social support system
Risk factors leading to Depression in the Grieving process
Slide39Geriatric depression
Prevalence of geriatric depression is much higher in medical settings than in the community -30%.
50% of nursing home residents are at risk to develop depression.
Cognitive impairment is an expected complication in elderly patients who develop depression
Slide40Under diagnosis of depression in the elderly
Under reporting of symptoms
More focus on physical symptoms
More
anhedonia
than
sadnesss
Subsyndromal
depression not meeting criteria
Medical illness detection overshadow the diagnosis of depression
Slide41Slide42Slide43Co-morbidity and complications of late life depression
Depression worsens outcomes and prognosis of medical illnesses
Depression lengthens hospital stay
Depression increases perception of ill health
Depression increases economic burden on the health care system
Depression worsens disability
Depression also results in increased suicide risk
-White men over the age of 65 has the highest suicide rate
Slide44Risk factors for suicide in the elderly
Loneliness and poor social support
Presence of psychiatric disorder
Presence of fire arm
Impaired ability with IADLs
Medical co-morbidity
Slide45Treatment options for Depression in the elderly
SSRIs
TCAs
MAOIs
Bupropion
Mirtazapine
Augmenting agents
ECT
Psychotherapy
Slide46Characteristics of Delirium
Disturbance of consciousness
Abnormal
cognition
Acute onset
and fluctuating in
course
Multifactorial etiology
Hyperactive
, hypoactive, and mixed forms
Slide47Characteristics of delirium
Misdiagnosis is frequent – confused with depression and mania
May develop over hours to days.
Abrupt onset more common.
The line between dementia and delirium is often unclear.
Slide48Etiology of delirium
Etiology -
Multifactorial
Infections
Toxins
, including
drugs
Substance withdrawal
Organ
failure: heart, liver, kidney,
etc
Metabolic derangements
Primary
brain disorders
Slide49Pathogenesis of Delirium
Pathogenesis
:
No specific structural brain lesion identified:
EEG
showing slow waves but nonspecific
Depleted acetylcholine
Dopamine, GABA, serotonin, acetylcholine imbalance
Cytokine activation (sepsis)
Slide50Risk Factors
Dementia is the strongest risk factor – 25 to 75% of patients have dementia.
Other predisposing brain diseases: stroke, Parkinson
’
s
Advanced age
Severe medical illness
Hyponatremia
, dehydration, other metabolic problems
Anticholinergic drugs, sedative hypnotics, narcotics
Slide51Clinical Presentation
Disorientation
to place, time, situation
Impaired consciousness
Reduced awareness
Reduced or clouded consciousness with or without overt hallucinations
Slide52Clinical Presentation
Decreased ability to focus, sustain, or shift attention
Decreased selective attention
Distractibility
Cognition is made worse by inattention.
Speech:
Tangential
Poorly organized
Slowed, slurred
Word finding difficulties
Slide53Clinical Presentation
Impaired registration, recent/remote
memory
with associated confabulation
Perceptual abnormalities:
May be agitated
in response to hallucinations
Slide54Diagnosis
History from family and/or caregivers
Bedside observations
DSM-IV diagnostic criteria
Reliable diagnostic instruments:
Confusion Assessment Method
The Delirium Rating
Scale
Delirium
Symptom Review
Diagnostic errors are common in:
Hypoactive form
The setting of rapid fluctuations of cognition.
Slide55Differential Diagnosis
Dementia
Alzheimer dementia
Lewy
body dementia
D
epressive states
Psychotic disorders