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Mental health and Aging Vineeth Mental health and Aging Vineeth

Mental health and Aging Vineeth - PowerPoint Presentation

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Mental health and Aging Vineeth - PPT Presentation

John MD MBA Case of a new onset Bipolar Disorder A 60yearold righthanded previously successful and psychiatrically healthy businessman was brought by his family to a university hospital neuropsychiatry service for consultation regarding behavioral and personality changes ID: 933862

onset depression medical dementia depression onset dementia medical late schizophrenia symptoms psychotic disorder disorders risk disease social delirium common

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Slide1

Mental health and Aging

Vineeth

John MD MBA

Slide2

Case of a new onset Bipolar Disorder

A 60-year-old, right-handed, previously successful and psychiatrically healthy businessman was brought by his family to a university hospital neuropsychiatry service for consultation regarding behavioral and personality changes.

When he was age 55 years, his customarily excellent financial and social judgment began to decline. Over the next 4 years, his attention to personal hygiene deteriorated, his business decisions became financially and ethically unsound, his range of social interests narrowed dramatically, and he developed an insatiable "sweet tooth."

One month before the neuropsychiatric consultation, he had received a diagnosis of late-onset bipolar disorder and had begun treatment with lithium carbonate. When his serum lithium level reached the therapeutic range, his cognitive, behavioral, and motor function declined precipitously, prompting the consultation for a second diagnostic opinion. Is this patient’s presentation consistent with late-onset bipolar disorder? What assessments are needed to clarify his diagnosis

Slide3

Case of a new onset Bipolar Disorder

In the year preceding the consultation, his ability to maintain sleep diminished, he began spending money recklessly and impulsively and became unable to appreciate the feelings and concerns of others, and his speech and behavior took on a

perseverative

quality. Concurrently, he developed unprovoked, brief, frequent, and excessively intense episodes of tearfulness and laughing. These episodes lasted minutes at most, after which he would return to his usual

euthymic

emotional state.

Slide4

Case of a new onset Bipolar Disorder

One month before the neuropsychiatric consultation, he had received a diagnosis of late-onset bipolar disorder and had begun treatment with lithium carbonate. When his serum lithium level reached the therapeutic range, his cognitive, behavioral, and motor function declined precipitously, prompting the consultation for a second diagnostic opinion

.

Slide5

Slide6

Late onset psychosis

Psychosis of Alzheimer's disease

Late onset Schizophrenia

Late life delusional disorder

Psychotic disorders secondary to General Medical Conditions

Slide7

Psychosis in AD

Increased risk of agitation

Increase in aggression

Poor self care

Disruptive behavior

Wandering

High rate of institutionalization

Slide8

Psychosis in AD

Between 30 to 50 % of AD patients have psychotic symptoms

Psychotic symptoms are more prevalent as the disease progresses but are more common in the middle stages.

Visual hallucinations are more common than auditory hallucinations.

Slide9

Common themes of delusions in AD

Stealing

Stranger in the house

Spying

Impersonating the spouse or loved one

Slide10

Psychosis in other dementias

Dementia of

Lewy

bodies -VH and Delusions

Parkinson's Disease - Delusions and hallucinations

Vascular Dementia

Slide11

Treatment of Psychotic Symptoms in Dementia

Low dose antipsychotics are the norm.

Careful balancing of the risks and benefits need to be performed.

Slide12

Delusions in Dementia

Hallucinations in Dementia

Agitation in Dementia

Depressed Mood in Dementia

Devanand

et al. Archives of General Psychiatry 1997;54(3) 257-63

Slide13

Agitation in Dementia

Treat reversible causes of agitation-UTI, medications, alterations in renal functions, pain and discomfort

Behavioral Interventions

Antipsychotic medications

Anticonvulsants

Acetyl Cholinesterase Inhibitors/

Memantine

SSRIs and antidepressant therapy

Slide14

Factors affecting Psychosocial interventions

Individual biography

Individual’s personality

Coexisting physical and mental health problems

Person’s social relationships

Physical environment in which the person is living

Community and cultural understandings of tolerance for confusion and frailty

Extent and location of the disease

Slide15

Psychotherapeutic Interventions

Behavior management training

Caregiver training

Scheduled toileting

Reminiscence therapy

Validation therapy

Supportive therapy

Reality orientation

Art therapy

Slide16

Slide17

Slide18

Late onset Schizophrenia

Schizophrenia is characterized by it's onset in youth and subsequent deterioration of functionality.

Schizophrenia after 45 years of age was considered late onset by APA DSM III R, 1987. International consensus panel chose 40 years as the cut off point.

No such distinction is elaborated in DSM IV TR version.

Slide19

What are the distinct features of late onset schizophrenia

?

Lack of negative symptoms

Lack of thought disorder

More paranoid schizophrenia subtype

Presence of the features of

neurodegeneration

–CVAs.

More in women than in men

Patients who develop late onset schizophrenia were also noted to have sensory deficits - visual and hearing

Slide20

Differential diagnosis of late onset schizophrenia

Psychotic disorders secondary to general medical conditions

Psychotic symptoms which might be part of delirium

Early onset schizophrenia undetected

Mood disorders with psychotic features

Delusional disorders

Slide21

Slide22

Slide23

PDGMC vs

Schizophrenia

INDICATORS

PDGMC

SCHIZOPHRENIA

ONSET

SUDDEN

GRADUAL

DRUG/ALCOHOL HISTORY

TEMPORALLY RELATED

COMORBIDITY

MEDICAL HISTORY

COMMON

INFREQUENT

CONCOMITANT MEDS

FREQUENT

INFREQUENT

FAMILY

HISTORY

NOT FOR PSYCHOSIS

+/-

HALLUCINATIONS

MULTIMODAL

AUDITORY USUALLY

Slide24

Treatment of late onset schizophrenia

Atypical antipsychotics

Psychosocial treatments-social skills, CBT

Family interventions for relapse prevention

Slide25

Aging and Early onset Schizophrenia

Around 30% could show evidence for improvement and remission.

Cognitive deterioration is reasonably steady and do deteriorate significantly

Slide26

John Nash Jr

- “ A beautiful mind”

Slide27

John Nash, Jr

- In his own words

“But after my return to the dream-like delusional hypotheses in the later 60's I became a person of

delusionally

influenced thinking but of relatively moderate behavior and thus tended to avoid hospitalization and the direct attention of psychiatrists.

Thus further time passed. Then gradually I began to intellectually reject some of the

delusionally

influenced lines of thinking which had been characteristic of my orientation. This began, most recognizably, with the rejection of politically-oriented thinking as essentially a hopeless waste of intellectual effort.”

Slide28

Psychotic disorders due to general medical conditions in the elderly

Stroke

Parkinson's disease

Epilepsy

Herpes Encephalitis

Thyroid and adrenal disorders

Folate

, B

12

deficiencies

Systemic lupus

erythematosus

Alcoholic

hallucinosis

Slide29

Medications causing psychotic symptoms

Levadopa

Bromicriptine

Amantadine

Isoniazid

Corticosteroids

Amphetamines

Methylphenidate

Lidocaine

Cimetidine

Slide30

Mood disorders secondary to general medical conditions

Rate of depression in the medical population is 12 to 20%.

Many physical illnesses and medications can cause symptoms mimicking depression.

Slide31

Common medical conditions causing depression

Strokes

Parkinson's Disease

Hypothyroidism

Addison's Disease

Occult carcinoma of the Pancreas

Collagen vascular disease

Multiple sclerosis

Slide32

Most common medications causing depression

Antihypertensives

-

reserpine

and methyl

dopa

Steroids

Slide33

Secondary Mania

Stroke

Right hemisphere cerebral

neoplasms

Multiple sclerosis

Encephalitis

Syphilis

Head injury

Uremia

Slide34

Secondary Mania

Corticosteroids

Thyroxin

Levodopa

Bromocriptine

Amphetamines

Cimetidine

Slide35

Dimensions of Grief and Bereavement

Emotional and cognitive experiences

Coping strategies

Continuing relationship with the deceased

Health, occupational and social functioning

Relationships

Social identity and Self esteem

Slide36

Complications of Grief and Bereavement

Morbidity

Increased somatic complaints

Worsening of pre existing illnesses

Increased use of medical services

Mortality

Widowers: highest risk in the first six months

Widows: period of risk delayed by 1or 2 years.

Slide37

Psychiatric complications of grief

Substance use

Anxiety symptoms

PTSD

Depression

Slide38

Unnatural sudden unexpected death

Preexisting mood disorder

Early, intense depressive reaction after the loss

Poor physical health

Increased alcohol consumption

Family history of major depression

Poor social support system

Risk factors leading to Depression in the Grieving process

Slide39

Geriatric depression

Prevalence of geriatric depression is much higher in medical settings than in the community -30%.

50% of nursing home residents are at risk to develop depression.

Cognitive impairment is an expected complication in elderly patients who develop depression

Slide40

Under diagnosis of depression in the elderly

Under reporting of symptoms

More focus on physical symptoms

More

anhedonia

than

sadnesss

Subsyndromal

depression not meeting criteria

Medical illness detection overshadow the diagnosis of depression

Slide41

Slide42

Slide43

Co-morbidity and complications of late life depression

Depression worsens outcomes and prognosis of medical illnesses

Depression lengthens hospital stay

Depression increases perception of ill health

Depression increases economic burden on the health care system

Depression worsens disability

Depression also results in increased suicide risk

-White men over the age of 65 has the highest suicide rate

Slide44

Risk factors for suicide in the elderly

Loneliness and poor social support

Presence of psychiatric disorder

Presence of fire arm

Impaired ability with IADLs

Medical co-morbidity

Slide45

Treatment options for Depression in the elderly

SSRIs

TCAs

MAOIs

Bupropion

Mirtazapine

Augmenting agents

ECT

Psychotherapy

Slide46

Characteristics of Delirium

Disturbance of consciousness

Abnormal

cognition

Acute onset

and fluctuating in

course

Multifactorial etiology

Hyperactive

, hypoactive, and mixed forms

Slide47

Characteristics of delirium

Misdiagnosis is frequent – confused with depression and mania

May develop over hours to days.

Abrupt onset more common.

The line between dementia and delirium is often unclear.

Slide48

Etiology of delirium

Etiology -

Multifactorial

Infections

Toxins

, including

drugs

Substance withdrawal

Organ

failure: heart, liver, kidney,

etc

Metabolic derangements

Primary

brain disorders

Slide49

Pathogenesis of Delirium

Pathogenesis

:

No specific structural brain lesion identified:

EEG

showing slow waves but nonspecific

Depleted acetylcholine

Dopamine, GABA, serotonin, acetylcholine imbalance

Cytokine activation (sepsis)

Slide50

Risk Factors

Dementia is the strongest risk factor – 25 to 75% of patients have dementia.

Other predisposing brain diseases: stroke, Parkinson

s

Advanced age

Severe medical illness

Hyponatremia

, dehydration, other metabolic problems

Anticholinergic drugs, sedative hypnotics, narcotics

Slide51

Clinical Presentation

Disorientation

to place, time, situation

Impaired consciousness

Reduced awareness

Reduced or clouded consciousness with or without overt hallucinations

Slide52

Clinical Presentation

Decreased ability to focus, sustain, or shift attention

Decreased selective attention

Distractibility

Cognition is made worse by inattention.

Speech:

Tangential

Poorly organized

Slowed, slurred

Word finding difficulties

Slide53

Clinical Presentation

Impaired registration, recent/remote

memory

with associated confabulation

Perceptual abnormalities:

May be agitated

in response to hallucinations

Slide54

Diagnosis

History from family and/or caregivers

Bedside observations

DSM-IV diagnostic criteria

Reliable diagnostic instruments:

Confusion Assessment Method

The Delirium Rating

Scale

Delirium

Symptom Review

Diagnostic errors are common in:

Hypoactive form

The setting of rapid fluctuations of cognition.

Slide55

Differential Diagnosis

Dementia

Alzheimer dementia

Lewy

body dementia

D

epressive states

Psychotic disorders