PPT-Current Therapy in Type 2 Diabetes:

What Follows Metformin James R Gavin III MD PhD CEO amp Chief Medical Officer Healing Our Village Inc Clinical Professor of Medicine Emory University School of Medicine Atlanta Georgia USA. People with diabetes have high blood glucose also called high blood sugar or hyperglycemia Diabetes is a disorder of metabolism the way the body uses digested food for energy The digestive tract breaks down carbohydratessugars and starches found in A lifetime risk challenge. Priorities in the management . of . type 2 diabetes:. Past, present and future. Sir George Alberti, MD. Diabetes UK Chairman. Newcastle. , United Kingdom. Cardio. Diabetes . A lifetime risk challenge. Priorities in the management . of . type 2 diabetes:. Past, present and future. Sir George Alberti, MD. Diabetes UK Chairman. Newcastle. , United Kingdom. Cardio. Diabetes . 1. Risk Factors for Prediabetes and Type 2 Diabetes. Family history of diabetes mellitus. Cardiovascular disease. Being overweight or obese. Sedentary lifestyle. Nonwhite ancestry. Previously identified impaired glucose tolerance, impaired fasting glucose, and/or metabolic syndrome. Years from . diagnosis. 0. 5. -10. -5. 10. 15. Pre-diabetes. Onset. Diagnosis. Insulin secretion. Insulin “efficiency”. Ramlo-Halsted BA, Edelman SV. . Prim Care. . 1999;26:771-789 Nathan DM. . N Engl J Med. . 1. Type 1 Diabetes Mellitus. Characterized by absolute insulin deficiency. Pathophysiology and etiology. Result of pancreatic beta cell destruction. Prone to ketosis. Total deficit of circulating insulin. Chapter 34. Diane K. Wherrett . MD FRCPC, . Céline Huot . MD MSc FRCPC, . Laurent Legault . MD FRCPC, . Josephine Ho . MD MSc FRCPC, . Meranda Nakhla . MD MSc FRCPC. , Elizabeth Rosolowsky . MD MPH FAAP FRCPC. results in increased concentrations of glucose in the blood, which in turn damage the blood vessels and nerves.. Diabetes mellitus is a group of metabolic disorders sharing the common feature of . hyperglycemia. In both of the common types of diabetes, environmental factors interact with genetic susceptibility to determine which people develop the clinical syndrome, and the timing of its onset.. However, the underlying genes, precipitating environmental factors and pathophysiology differ substantially between type 1 and type 2 diabetes.. This . topic will review the pathogenesis of hypertension in patients with diabetes mellitus and the three major treatment issues:. The evidence supporting benefit from the treatment of hypertension. Type 2 Diabetes. High blood glucose. Insulin secretion from pancreas. ↑ Glucose absorption by muscle. Low blood glucose. Eat. Analyzed genome sequence of Steve Quake. Rare protein altering SNPs . But usually do not know what the gene does, so difficult to know if the mutation is causing a trait.. Definition. Type 1 Diabetes. : This refers to a genetically based condition in which the cells in the pancreas that normally produce a hormone called “Insulin” stop functioning. This often appears in childhood or early adolescence. The only treatment for Type 1 Diabetes is insulin replacement (by pump or injection). Without adequate supplementary insulin, blood sugar levels dramatically increase and glucose “spills over” into the urine.. Type 1 Diabetes: Before and After Insulin. 1. . The Case for Serendipity. Available at: http://www.mc.vanderbilt.edu/lens/article/?id=221&pg=999. Accessed April 6, 2010.. 2. . Westman. et al. . Perspectives in Biology and Medicine. chronic metabolic disorder that prevents the body to utilize glucose completely or partially. . It is . characterised. by raised glucose in the blood and altered carbohydrate , protein and fat metabolism. .