PPT-1 B Cell Activation Abul K.

Abbas UCSF FOCiS 2 Lecture outline Functions of antibodies B cell activation the role of helper T cells in antibody production Therapeutic targeting of B cells 3 Humoral immunity is the defense mechanism against extracellular microbes . non-AIDS Morbidity. Peter W. Hunt, MD. Associate Professor of Medicine. UCSF HIV/AIDS Division. A shift in focus…. T cell activation as a target for interventions in the pre-ART era. Monocyte activation and inflammation a target during treated HIV disease. Laurence WEISS. Predictive biomarkers in HIV infection. Reflect. The extent of immune deficiency. The level of HIV replication and of HIV reservoir. The level of chronic immune activation/inflammation. cell-associated. HIV-DNA level in PBMCs in . viremic. patients . with acute or chronic HIV-1 infection. Laurence Weiss. , Mathieu F. Chevalier, Lambert Assoumou, . Céline Didier. , Pierre-Marie Girard. Inside-Outside-Inside… What’s the focus?. Cells utilize . i. ntegrins to interact physically with the extracellular environment in a number of different ways. There has been a lot of focus on how outside-in mechanisms affect cell behavior. Hanrahan. and Weinberg, “Hallmarks of Cancer,” Cell, 2000.. Pathways. Hanrahan. and Weinberg, “Hallmarks of Cancer,” Cell, 2000.. Pathways. EGFR. : . DNA . synthesis and cell . proliferation . Bethesda, Maryland. Immune Activation, HIV Persistence, and the Cure. What We Talk About When We Talk About. Immune Activation. Normal innate response to viral infection in the acute phase of the infection. Focus on Integrins. John Cooper. Dept of Biochemistry & Molecular Biophysics. www.cooperlab.wustl.edu. jacooper@wustl.edu. November 19, 2019. Goals of lecture. Context: Cell adhesion and ECM molecules. Activation of T and B cells expressing Ag-specific receptors results in:. proliferation.. Differentiation into . effector cells. and memory cells.. The activation of T cells leads to the synthesis and secretion of cytokines that affect many different cell types.. :. Current . Concepts. Lawrence B. Afrin, M.D.. Division of Hematology, Oncology & Transplantation. University of Minnesota. Wellapalooza. 2016. June 11, . 2016. Learning Objectives & Disclaimers. Rodriguez. Sahat Yalkabov. TCR Signaling Pathway. TCR (T cell receptor). Molecule found on T Cells. Response for recognizing antigens on . MHC (Major Histocompatibility . Complex). T cell is activated when TCR engages with antigen. and Weinberg, “Hallmarks of Cancer,” Cell, 2000.. Pathways. Hanrahan. and Weinberg, “Hallmarks of Cancer,” Cell, 2000.. Pathways. EGFR. : . DNA . synthesis and cell . proliferation . look for activation of . Cells and . Blood Cells/Factors. Intercellular/Cell-Surface Elements. Selective alteration/dysregulation . of junctional proteins (. Claudins. , . . Occludin. , JAM, ...). Cell Adhesion proteins (E-Selectin, . Antibody- B cell checkpoints in autoimmune SamuelJ.S.Rubin, MichelleS.Bloom and WilliamH.RobinsonAbstract B cells have important functions in the pathogenesis of autoimmune diseases, including Cem Akin, MD, PhD Professor of Medicine University of Michigan Department of Internal Medicine Division of Allergy and Clinical Immunology Disclosures • Consultancies – Novartis ( Midostaurin tria