Cells and Blood CellsFactors IntercellularCellSurface Elements Selective alterationdysregulation of junctional proteins Claudins Occludin JAM Cell Adhesion proteins ESelectin ID: 932451
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Activation of Endothelial Cells and Blood Cells/Factors
Intercellular/Cell-Surface ElementsSelective alteration/dysregulation of junctional proteins (Claudins, Occludin, JAM, ...)Cell Adhesion proteins (E-Selectin, ICAM, PECAM,…)
Extracellular/ Blood-Cell ElementsWhite blood cell activation (LFA-1,…)Cytokine Release (TNFα, IL-1β, …)Autoregulation dysfunctionDiapedesisReactive Oxygen Species
Intracellular ResponseTranscription factor alteration (HIF-1, EGR, NFκB,...)Waste removal/ efflux mechanismIon channel (Na/K/2CL cotransporter, ...)Nutrient transporters (GLUT-1, LNAA, ...)Metabolism (ATP regulation, glucose)Reactive Oxygen Species
Capillary Leak
Local IschemiaScavenging of damaged cellsInterstitial EdemaTissue damage Chronic / Long-term Effects ???
-Perivascular tissue damage-Cytoskeletal / Tight Junction Protein Changes
-Cytotoxic Enzymes-ROS
Diapedesis
Endothelial Retraction
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