PPT-Establishing a model for macular degeneration using CRISPR-Cas9 gene editing and human

A Neiteler 1235 S Borooah 6 BT Selvaraj 235 K Burr 235 B Dhillon 24 JA Ross 1 S Chandran 235 1 Tissue Injury and Repair Group 2 Centre for Clinical Brain Sciences . Presented By :. Amna. Muhammad. 09-Arid-1536. Ph. D Scholar . Biochemistry. 1. st. Semester. 12/16/2014. 1. Contents. History. Functional analysis of a gene. RNA . interfernce. . siRNA. shRNA. miRNA. Breakthrough in genome editing.. The most important scientific result . of the year 2015.. “Science“,18 December 2015. I will report first about. Duchenne muscular dystrophy,. because there were serious problems . Nick Turner. Bio 446 Fall 16. Review. siRNA. dsRNA. microRNA. Immunity. Gene Regulation. Enzymatic breakdown of RNA. RNA Interference. RNAi. The use of RNA to inhibit gene expression.. Guiding RISC (RNA Induced Silencing Complex) cleave and degrade specific segments of RNA. The Wonderful World of CRISPR. As told by Professor Peter Shepherd. To do precise genetic engineering we need to be able to find and specifically modify regions of DNA. But the human genome has 3,000,000,000 base pairs so how are we going to find a 20 base pair region in this huge sea of DNA ? . CRISPR Babies: Background and Ethics By: Austin Guse and Kaitlyn Curtis What is a CRISPR baby? An organism, specifically a human child, that has had its genetics altered in one way or another and has successfully been born or is still in guestation. Filipa Lopes. . “Plants for Life” International PhD Program – 2017. (course “Plant Biotechnology for Sustainability and Global Economy”). . What. . is. . plant. . breeding. ?. Is the art and science of changing certain traits of plants over time in order to introduce desired characteristics. Genomics. Lesson 12. , presentation 3. Hardison. (many slides from Dr. . Cooduvalli. . Shashikant. ). 4/26/15. 1. Genome Editing . Removal, modification, or addition of a functional element into the genome of a living cell or organism. Describe the Gene Editing Technology (CRISPR-Cas9, ZNF, TALENS, Meganucleases) . Describe . the target gene, function of the target gene. and . the desired effect of the target gene in the system (in-vitro/in vivo) . How can we advance CRISPR from a revolutionary research tool to a level of precision and efficiency that will enable us to target ANY genetic disease?. DUAL OMNI™ . TECHNOLOGY PLATFORMS. Novel CRISPR Nuclease Discovery Platform. González. Master in . Advanced. . Genetics. Universitat. . Autònoma. de Barcelona. GENOMICS. Introduction. Francisco J. M. Mojica . CRISPR. 2000. Source. : . Doudna. . y . Charpentier. , 2014. Introduction. for creation of. p53 knock-outs in . human . glioma . cells. :. a. research proposal by . gus. . thomas. Overview and Introduction:. Glioblastoma Multiforme (GBM):. Aggressive brain cancer. Very poor prognosis. iii TABLE OF CONTENTS ...................................................................................1I. STATEMENT OF THE PROBLEM.......................................3 A. Description and Classi successfully applied to directly produce low-copy integrated transgenic lines in C. eleganss10]. High copy integrated arrays are prone to be silenced, yet low-copy transgenes permit relatively stable DEFINITIONS Genome Editing : This is a type of genetic engineering in which DNA is inserted, replaced, or removed from a genome using artificially engineered nucleases, or “molecular scissors”.