Drvahedian ardakani Medical oncologist 91115 Neuroendocrine tumors NETs are derived from the diffuse neuroendocrine system which is made up of peptide and amineproducing ID: 934832
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NEUROENDOCRINE TUMORS
Dr.vahedian
ardakani
Medical
oncologist
91/11/5
Slide2Neuroendocrine tumors (NETs) are derived from the diffuse neuroendocrine system, which is made up of peptide- and amine-producing cells with different hormonal profiles depending on their site of origin.
Slide3Pathologists cannot differentiate benign from malignant carcinoid tumors based on histologic analysis, nor can they histologically differentiate pancreatic endocrine tumors from carcinoidtumors. Malignancy can only be determined by localinvasion or distant metastases.
Slide4Carcinoid tumors synthesize bioactiveamines and peptides, includingneuron-specific enolase (NSE),5-hydroxytryptamine serotonin (5-HT), synaptophysin, and chromogranin A and C, andother peptides like insulin, growth hormone,
neurotensin,adrenocorticotropic hormone (ACTH), j3\
melanocytestimulating
hormone, gastrin, pancreatic polypeptide, calcitonin,
substance P, other various
tachykinins
(neuropeptide- K),
growth hormone-releasing hormone,
bornbcsin
, and various
growth factors such as transforming growth factor-S,
plateletderived
growth
factor, and fibroblast growth
factor-j3
Slide5Slide6Slide7Neuroendocrine tumors (NETs) arising at different sites within the body are classified according to their histologic features. All commonly used classification systems reflect a basic separation between more indolent, well differentiated tumors (traditionally referred to as carcinoids, islet cell, or pancreatic NETs), and far more aggressive poorly differentiated types that behave clinically more like small cell neuroendocrine tumors.
Slide8Slide9Neuroendocrine tumors of the lung encompass a spectrum of tumors, including low-grade typical carcinoid, Intermediategrade atypical carcinoid
, high-grade large cell
neuroendocrine
carcinoma (LCNEC),
and SCLC
Slide10Carcinoid tumors are rare, but are the most common gastrointestinal neuroendocrine tumor
Slide11Carcinoids arise from enterochromaffin cells of the gastrointestinal tract. They have traditionally been classified based upon their origin from the embryonic divisions of the alimentary tract; the foregut, midgut, or hindgut. In addition, they are classified based upon histologic characteristics as "typical" or "atypical" (anaplastic).
Slide12the majority of carcinoids were located in the gastrointestinal tract (55 percent) and bronchopulmonary system (30 percent) Within the gastrointestinal tract, most carcinoids arose in the small intestine (45 percent, most commonly in the ileum), followed by rectum (20 percent), appendix (16 percent), colon (11 percent), and stomach (7 percent).
Slide13Slide14The distinction between benign and malignant carcinoid is based upon the presence or absence of metastases rather than histology alone. The metastatic potential of carcinoids correlates best with the size and the site of the primary tumor. .Clinical symptoms may be general, or they may correlate with the location of the tumor and be organ related.
Slide15Symptoms of the carcinoid syndrome (eg, flushing and diarrhea) are infrequent, occurring in approximately 5 to 7 percent of patients. The frequency of carcinoid syndrome varies with tumor site and presence of metastases. Among patients with intestinal carcinoid tumors, the carcinoid syndrome does not occur in the absence of liver metastases.
Slide16Slide17Gastric carcinoids may present with peptic ulcer disease, abdominal pain, or bleeding. Gastric tumors are subclassified into types that have different presentations and malignant potential
Slide18Small intestinal carcinoids may present with abdominal pain and/or intermittent obstruction. Appendiceal carcinoids are the most common neoplasm found in the appendix; they are most often discovered incidentallyTransverse, descending colon, and rectum tumors may present with changes in bowel habit, obstruction, or bleeding. .
Slide19Ovarian carcinoids can produce the carcinoid syndrome without hepatic metastases due to their direct drainage into the systemic circulation
Slide20Slide21Slide22The clinical value of SRS in the initial evaluation or routine follow up of patients with advanced NET has been called into question. Baseline SRS may still be useful, however, as the uptake of radiolabeled octreotide is predictive of a clinical response to therapy with somatostatin analogs
Slide23Slide24The predominant site of metastatic spread is the liver. Patients in whom metastatic disease is suspected should be evaluated with a triple-phase contrast-enhanced helical CT or an MRI scan to rule out liver metastases. Some physicians prefer MRI because of its greater sensitivity for liver metastases.
Slide25Changes in biochemical markers are associated with disease progression and/or response to treatment. Elevated urinary levels of 5-hydroxyindoleacetic acid (5-HIAA) are highly specific for serotonin-producing carcinoid tumors (ie, those arising in the midgut), although they are not sensitive. For non-serotonin producing carcinoids and pancreatic neuroendocrine tumors, serum chromogranin A (CGA) is a more sensitive than 5-HIAA, though serum levels of CGA can also be elevated in non-neuroendocrine related conditions.
Slide26Pancreatic neuroendocrine tumors (pNETs) are low- tointermediate-grade neoplasms that are thought to arise from the pancreatic islets. Also known as pancreatic endocrine tumors,islet cell carcinoma, or pancreatic carcinoid, pNETs account for a minority of pancreatic neoplasms and can be either functional or nonfunctional.
Slide27STAGING SYSTEMS FOR PANCREATICNEUROENDOCRINE TUMORS
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