PPT-Glycerophospholipids and Lipoproteins

Glycrophospholipids degradation Lipoproteins G L Y C E R O L FATTY ACID FATTY ACID PHOSPHOACYLGLYCEROL PHOSPHATE ALCOHOL Again this is the representation structure of glycerophospholipids. UNIT III:. Lipid Metabolism. I. . . Overview. Phospholipids . are polar, ionic compounds composed of an alcohol that is attached by a . phosphodiester. bridge to either . diacylglycerol. or sphingosine. . 5/e. Karen C. Timberlake. © 2016 Pearson Education, Inc.. 17.6 Steroids: Cholesterol, Bile Salts, and Steroid Hormones. High- and low-density lipoproteins transport cholesterol between the tissues and the liver.. Lipoproteins. are . types of . Compound Lipids /. Conjugated . Proteins. .. Lipoproteins . are . macromolecules. formed by aggregation of. . :. Lipids . (Neutral . and A. mphipathic ). Proteins. ( Apoprotein) in the human body.. Ray . Hreiche. (updated slides from . Mohana. . Ratnapalan. & Anna . Sher. ). (THANK YOU!!!). Learning Objectives . Explain the physiological functions of cholesterol in membrane stability.. Outline the synthesis of cholesterol from acetate.. Plasma lipids . 200 . Lipoproteins . 201 . Fatty acids . 200 . Disorders of lipid metabolism . 207 . Cholesterol . 201 . Investigation of hyperlipidaemias . 214 . FATTY ACIDS . Lipids play a critical role in almost all aspects of . Cholesterol. Rich in hydrocarbon. Polar group (usually small). Oleic acid. Lipids serve a wide variety of functions. Vitamin K. Surfactants. Protection. Membrane. components. Insulation. Energy storage. phospholipids . are . a family of lipids similar in structure to . triacylglycerols. ; they. include . glycerophospholipids. . and . sphingomyelin. .. Glycerol. PO. 4. Amino . alcohol. Fatty acid. Fatty acid. Learning. . Objectives. The structure and composition of lipoproteins. Exogenous dietary fat transport vs. endogenous fat transport systems. Key enzymes involved in lipoprotein metabolism. Key cholesterol transporting lipoproteins and the relationship between their concentrations and the incidence of cardiovascular diseases. .. Importance of lipoproteins formation. .        . 1- . Lipids are water insoluble substance and can not be trasported in an aqueous medium (blood plasma )..             . 2- in order to transport lipids between blood and different tissues they are associated with a protein to form water soluble complex . CVS. 2018/2. ND. SEMESTER. • Four major groups of lipoproteins are recognized: Chylomicrons transport lipids resulting from digestion Lipid Metabolism and . absorption.Derived. from intestinal absorption of TG . . Dr.Deepa.G.S. Associate Professor. Dept.of. Physiology. Lipoproteins. Molecular complexes that consists of lipids and proteins. They function as transport vehicles for lipids in plasma. Lipoproteins-Structure. D.Pharm. , . Bpharm. , MSc ). O. utl. i. ne. Introduction. Definition of terminologies. Lipoprotein disorders. Types of dyslipidemia. Approaches to Management . Role. . and. . responsibili. ty of. . They bind with . soluble . protein. complexes . called. . lipoproteins. Lipids . can . be derived from food (exogenous) or synthesized. in the body (endogenous). The water-soluble (polar). groups of proteins, phospholipids and free cholesterol. Main lipids in the blood are the triglycerides and cholesterol.. Insoluble in the water.. Transport in the blood is via lipoproteins. Triglycerides. Glycerol with 3 attached fatty acids. Exogenous source : Dietary.