PPT-Glycerophospholipids and Lipoproteins

Glycrophospholipids degradation Lipoproteins G L Y C E R O L FATTY ACID FATTY ACID PHOSPHOACYLGLYCEROL PHOSPHATE ALCOHOL Again this is the representation structure of glycerophospholipids. 1. What is Cholesterol?. A waxy substance – technically a sterol (unsaturated steroid alcohol). 75% of your cholesterol is made in your liver, the rest is absorbed from food. Cholesterol travels in particles called lipoproteins: high-density lipoproteins (HDL) and low-Density Lipoproteins (LDL). Learning outcome. Most cholesterol is synthesised by the liver from saturated fats in the diet. Cholesterol is a component of cell membranes and a precursor for steroid synthesis. High-density lipoprotein (HDL) transports excess cholesterol from the body cells to the liver for elimination. This prevents accumulation of cholesterol in the blood. Low-density lipoprotein (LDL) transports cholesterol to body cells. Most cells have LDL receptors that take LDL into the cell where it releases cholesterol. Once a cell has sufficient cholesterol a negative feedback system inhibits the synthesis of new LDL receptors and LDL circulates in the blood where it may deposit cholesterol in the arteries forming atheromas. A higher ratio of HDL to LDL will result in lower blood cholesterol and a reduced chance of atherosclerosis. . UNIT III:. Lipid Metabolism. I. . . Overview. Phospholipids . are polar, ionic compounds composed of an alcohol that is attached by a . phosphodiester. bridge to either . diacylglycerol. or sphingosine. . Ceramide+carbohydrate. (. glucose,galactose,oligosacchride. side chain)=GLYCOLIPID. Cerebrosides:. contain a single moiety, principally galactose. Sulfatides:. sulfuric esters of galactocerebrosides. : Learning Outcomes. State where cholesterol is synthesised. State the type . of . diet that can increase cholesterol levels in the blood. Give 2 reasons why cholesterol is important for cellular functions. 5/e. Karen C. Timberlake. © 2016 Pearson Education, Inc.. 17.6 Steroids: Cholesterol, Bile Salts, and Steroid Hormones. High- and low-density lipoproteins transport cholesterol between the tissues and the liver.. References: Garrett/Grisham . Biochemistry . (4. th. . ed. ). , . chs. . 23 and sections of 24. Berg, . Tymoczko. & . Stryer. . Biochemistry . (6ht . ed. )., sections of . Dr. . Haidar. F. Al-. Rubaye. . Lipids are an essential nutrient with diverse functions. Lipids, also known as fats and oils, are:. One of the 6 main groups of nutrients absorbed from the diet. A major source of energy that can be stored over long periods (body fat). Plasma lipids . 200 . Lipoproteins . 201 . Fatty acids . 200 . Disorders of lipid metabolism . 207 . Cholesterol . 201 . Investigation of hyperlipidaemias . 214 . FATTY ACIDS . Lipids play a critical role in almost all aspects of . PSC 3110 – Fall semester 2008. Introduction. Definition: water insoluble compounds. Most lipids are fatty acids or ester of fatty acid. They are soluble in non-polar solvents such as petroleum ether, benzene, chloroform. CVS. 2018/2. ND. SEMESTER. • Four major groups of lipoproteins are recognized: Chylomicrons transport lipids resulting from digestion Lipid Metabolism and . absorption.Derived. from intestinal absorption of TG . . Cardiovascular . Block. Dr. . Usman. . Ghani. Objectives. By the end of this lecture, the First Year students will be able to:. Correlate . the imbalance . in lipoprotein metabolism with the development of . D.Pharm. , . Bpharm. , MSc ). O. utl. i. ne. Introduction. Definition of terminologies. Lipoprotein disorders. Types of dyslipidemia. Approaches to Management . Role. . and. . responsibili. ty of. . They bind with . soluble . protein. complexes . called. . lipoproteins. Lipids . can . be derived from food (exogenous) or synthesized. in the body (endogenous). The water-soluble (polar). groups of proteins, phospholipids and free cholesterol.