PPT-Cholesterol and C.V.D.

Learning outcome Most cholesterol is synthesised by the liver from saturated fats in the diet Cholesterol is a component of cell membranes and a precursor for steroid synthesis Highdensity lipoprotein HDL transports excess cholesterol from the body cells to the liver for elimination This prevents accumulation of cholesterol in the blood Lowdensity lipoprotein LDL transports cholesterol to body cells Most cells have LDL receptors that take LDL into the cell where it releases cholesterol Once a cell has sufficient cholesterol a negative feedback system inhibits the synthesis of new LDL receptors and LDL circulates in the blood where it may deposit cholesterol in the arteries forming atheromas A higher ratio of HDL to LDL will result in lower blood cholesterol and a reduced chance of atherosclerosis . High blood cholesterol is one of the major risk factors for heart disease A risk factor is a condition that increases your chance of getting a disease In fact the higher your blood cholesterol level the greater your risk for developing heart disease egg yolk. Lipids. Lipids. are. Biomolecules. that contain fatty acids or a steroid nucleus.. Soluble in organic solvents but not in water.. Named for the Greek word . lipos. , which means “fat.”. BIOSYNTHESIS OF CHOLESTEROL. Cholesterol is doubtless the most publicized lipid, notorious because of the strong correlation between high levels of cholesterol in the blood and the incidence of human cardiovascular diseases.. The Good, the Bad and the Ugly. What is Cholesterol?. Cholesterol is a waxy fat steroid. It is manufactured in the :. Liver. Intestines. Adrenal glands. Sex organs. Cholesterol is only synthesized in animals. Cholesterol. Is the most abundant . steroid. in the body.. Is a . waxy. substance found in all of the body cells. . Has . methyl. CH. 3. - groups, alkyl chain, and -OH attached to the steroid nucleus.. UNIT III:. Lipid Metabolism. HDL . comprise a heterogeneous family of lipoproteins with a complex metabolism that is not yet completely understood. . HDL particles are formed in blood by the addition of lipid to . Discover the truth and the facts about The Oxidized Cholesterol Strategy™ PDF, eBook by Blue Heron Health News. Click \"SHARE\" and \"DOWNLOAD\" to read the document offline. Cholesterol is an essential lipid constituent of cell membranes. Cholesterol is a precursor of steroid hormones and of bile acids. Intermediates of cholesterol biosynthesis are required to make vitamin D and for posttranslational modification of membrane proteins. Ray . Hreiche. (updated slides from . Mohana. . Ratnapalan. & Anna . Sher. ). (THANK YOU!!!). Learning Objectives . Explain the physiological functions of cholesterol in membrane stability.. Outline the synthesis of cholesterol from acetate.. Itzel . Vazquez-Vidal . and Peter J.H. . Jones. University . of Manitoba, Richardson Centre for Functional Foods and . Nutraceuticals.. 1. Principles of Nutrigenetics and . Nutrigenomics . Diet and Cardiovascular Disease. ????????????????? ? Cholesterol is a fatty substance, vital for good health. It helps form cell membranes, various hormones, bile and vitamin D. We get some cholesterol from our diet but most is made Advice f rom the National Lipid Association Clinician’s Lifestyle Modification Toolbox P rovided as part of the Clinician’s Lifestyle Modification Toolbox on Lipid.org. Learn more at LearnYourLi Peter Espenshade. Department of Cell Biology . Cellular Control of Metabolism. Jürgen Berger/Max Planck Institute. Cells require tight regulation of metabolism to maintain . homeostasis and viability.. Dr. Carolyn K. Suzuki. 1. To compare and contrast the properties of apolipoprotein particles (e.g. chylomicrons, LDL, HDL), with respect to their composition, metabolism and transport. . To distinguish the different biochemical pathways that can be potentially targeted pharmacologically to control plasma apolipoprotein levels and manage cardiovascular disease..