PPT-Cholesterol metabolism Biological significance of cholesterol

Cholesterol is an essential lipid constituent of cell membranes Cholesterol is a precursor of steroid hormones and of bile acids Intermediates of cholesterol biosynthesis are required to make vitamin D and for posttranslational modification of membrane proteins. AANUIIOU WELL ALANEIELOWINAUAE fats trans fats and cholesterol that includes a VAIEYOUI VEGEALEANA EEANLOW A dairy products AOILYWIEPEWEE OOELEANUOMEA IMALLVIILEAANOW AWAYEAAOOOUOEMEAEMOVEE skin from poultry 3UIUEMEALEOLOW MEAMAINIEO regular entrees But when you have too much in your blood it can build up on the walls of your arteries This can lead to heart disease and strokeleading causes of death in the United States Are you at risk About one in every six adult Americans has high cholesterol It is made in the liver and released into the bloodstream You can also get cholesterol from the food you eat It is important to get your cholesterol checked and learn how to manage your cholesterol The different types of cholesterol HDL Highdensity Digestion and Absorption of Dietary Lipids.  . Lipids are taken in the diet . mainly as . triacylglycerol. . In addition, small amounts of phospholipids, cholesterol, . carotenoids. and fat-soluble vitamins are taken in diet.. Dr. Nikhat Siddiqi. 1. Overview. Cholesterol, the characteristic steroid alcohol of animal tissues, performs a number of essential functions in the body. . C. holesterol is a structural component of all cell membranes, modulating their fluidity, and, in specialized tissues, cholesterol is a precursor of bile acids, steroid hormones, and vitamin D. . Chapter 29, . Stryer. Short Course. Lipid anabolism. Triacylglyderides. Membrane components. Cholesterol. Regulation. Steroids. TAG Synthesis. Mainly in Liver. Packaged in chylomicrons. Cholesterol Biosynthesis. UNIT III:. Lipid Metabolism. HDL . comprise a heterogeneous family of lipoproteins with a complex metabolism that is not yet completely understood. . HDL particles are formed in blood by the addition of lipid to . Fat and Glycerophospholipid Synthesis. 1. 2. 3. 1. 2. 3. 1. 2. 3. Phosphatidic . Acid. Glycerol-3-P. Fat (Triacylglycerol). Glycerophospholipids. Fat Breakdown. Signaling. Catalysis. Glycero. Phospho. Plasma lipoproteins. Prof. Mamoun Ahram. Resources. This lecture. Lippincott’s Biochemistry, Ch. 18. Characteristics of lipoproteins. Lipoproteins function to . Solubilize and carry plasma lipids. Transport lipids to (and from) the tissues. Ray . Hreiche. (updated slides from . Mohana. . Ratnapalan. & Anna . Sher. ). (THANK YOU!!!). Learning Objectives . Explain the physiological functions of cholesterol in membrane stability.. Outline the synthesis of cholesterol from acetate.. What are lipids?. If so, how are these water insoluble molecules transported from one tissue to other through an aqueous environment?. Mark the hydrophobic and hydrophilic parts on these molecules. FA. Dr. . Haidar. F. Al-. Rubaye. . Lipids are an essential nutrient with diverse functions. Lipids, also known as fats and oils, are:. One of the 6 main groups of nutrients absorbed from the diet. A major source of energy that can be stored over long periods (body fat). Functions of Cholesterol. . a precursor of. steroid hormones. (progesterone, testosterone, . estradiol. , cortisol, etc.) . a precursor of. bile acids. . a precursor of . vitamin . D. important component of many mammalian . ????????????????? ? Cholesterol is a fatty substance, vital for good health. It helps form cell membranes, various hormones, bile and vitamin D. We get some cholesterol from our diet but most is made