PPT-Genetic Polymorphism in Drug Metabolism – CYP450

Isoenzymes Presented by Lahari Paladugu PharmD 0910 Presented on February 7 2014 What is Genetic Polymorphism 1 The existence together of many forms of DNA sequences at . Copy Number Variations. and SNP Array. Xiaole Shirley Liu. and . Jun Liu. 2. Outline. Definition and motivation. SNP distribution and characteristics. Allele frequency, LD, population stratification. By Aidan Cross and Tom Grant. How many phases of drug . metabolism are there? (1 mark). 3 Phases. . What . is phase 1 of drug metabolism? (2). Provide a functional group (e.g. OH or NH. 2. ) to:. increase polarity of the drug. xenobiotic. . metabolism and . pharmacogenetics. George Howell III, . Ph.D. Sites of drug metabolism. Liver – responsible for the majority of drug metabolism. First pass metabolism. Kidney. GI. Lung. METABOLISM OR BIOTRANSFORMATION . The conversion from one chemical form of a substance to another. . The term metabolism is commonly used probably because products of drug transformation are called . &. Pharmacogenomics. Personalized Medicine. Drugs and Genes. Pharmacogenetics. : . Study . of the genetic factors that influence an organism's reaction to a drug . Pharmacogenomics: . Development . Yolande Lucire and Christopher Crotty . . Why do some people believe that they do?*. What is the link between illicit street drug use and being diagnosed with “treatment-refractory schizophrenia”?. . Gastrointestinal and Hepatic Systems. . Regulation of Drug Transport, Absorption, Distribution, Excretion and Metabolism. Dennis Paul, Ph.D.. Department of Pharmacology. 504-568-4740. rwainf@lsuhsc.edu. Department of Pharmaceutics. . . Drug metabolism or Biotransformation is the major mechanism for elimination of drug from the body.. . It is the process by which the drug is chemically modified . Dr Shaheen. Delivered By . Dr Naser . Drug interactions- objectives. Discuss Pharmacokinetic interactions. List . Pharmacodynamic. interactions. Comment . on common Drug- Food interactions. Drug interactions. Tam Nguyen. November 25, 2014. CHEM4201. Introduction . What is . prodrug. ?. Why use . prodrugs. ?. Classification of . prodrugs. Applications of . prodrugs. Esters. Enalapril. Conclusion. References. Symposium. March . 31, 2016. Inborn Errors of Metabolism:. Metabolomics. Gerard T. Berry, MD. Professor of Pediatrics, Harvard Medical School. Director, Metabolism Program. , . Boston Children’s Hospital. Liver dysfunction and Drugs metabolism Dr V.Sebghatollahi Isfahan university of medical science Liver Functions: Metabolism – Carbohydrate, Fat & Protein Secretory – Bile acids, bile salts Factors affecting Drug Metabolism Pharmaceutical Medicinal Chemistry-I Dr. Bilal Al-Jaidi Assistant Professor in Medicinal Chemistry and Drug Design Faculty of Pharmacy, Philadelphia University-Jordan Joseph McGraw, Pharm.D., M.P.H., Ph.D.. Associate Professor of Pharmaceutical Sciences . CUW School of Pharmacy . President and Chief Scientific Officer . Persotype. DX LLC. Background. Ph.D.-Biopharmaceutical Sciences.