PPT-Liver dysfunction and Drugs metabolism Dr V.Sebghatollahi

Liver dysfunction and Drugs metabolism Dr VSebghatollahi Isfahan university of medical science Liver Functions Metabolism Carbohydrate Fat amp Protein Secretory Bile acids bile salts. By Aidan Cross and Tom Grant. How many phases of drug . metabolism are there? (1 mark). 3 Phases. . What . is phase 1 of drug metabolism? (2). Provide a functional group (e.g. OH or NH. 2. ) to:. increase polarity of the drug. Soheil Altafi MD. 1/27/15. DILI- Table of Contents. Introduction. Epidemiology. Liver - Drug Metabolism. Factors influencing Drug Metabolism. Mechanisms of Drug-induced Hepatotoxicity. Clinical Presentation. Natalie . Craythorne. 1. st. February 2013. Aims for today. To know what a drug is and how they are classified. To understand where drugs come from. Be able to explain the “lock and key” and induced fit hypotheses. Natalie . Craythorne. 27. th. September. . 2013. Aims for today. To know what a drug is and how they are classified. To understand where drugs come from. Be able to explain the “lock and key” and induced fit hypotheses. METABOLISM OR BIOTRANSFORMATION . The conversion from one chemical form of a substance to another. . The term metabolism is commonly used probably because products of drug transformation are called . GLYCOGEN . Found in liver and skeletal muscles.. Represents 10% of weight of liver and 1-2% of muscles.. Stored in large cytosolic granules.. Elementary particles, . β. -particles consist of 50,000 glucose residues.. Soheil Altafi MD. 1/27/15. DILI- Table of Contents. Introduction. Epidemiology. Liver - Drug Metabolism. Factors influencing Drug Metabolism. Mechanisms of Drug-induced Hepatotoxicity. Clinical Presentation. . Gastrointestinal and Hepatic Systems. . Regulation of Drug Transport, Absorption, Distribution, Excretion and Metabolism. Dennis Paul, Ph.D.. Department of Pharmacology. 504-568-4740. rwainf@lsuhsc.edu. Integration Of Metabolism Metabolism Consist of Highly Interconnected Pathways The basic strategy of catabolic metabolism is to form ATP, NADPH , and building blocks for biosyntheses. 1. ATP is the universal currency of energy disease. Penny North-Lewis. Paediatric Liver Pharmacist. Leeds . Children’s Hospital. September 2019. Where is the liver?. What does the liver do?. Synthesis. . (e.g. albumin & clotting . factors, cholesterol). P.G.. 10.11.2020. Metabolic Profile of the Well-Fed (Absorptive) State. Metabolic Profile of the Postabsorptive State. Preferred Fuels in the Well-Fed and Fasting States. Metabolic Interrelationship. Dr. Ishfaq Bukhari. Pharmacology Unit. College of Medicine. KSU. 1. Alcohol: The mother of All Evils . 2. Ethyl alcohol (ethanol). . Ethyl alcohol (ethanol) is the most commonly abused drug in the world.. DILI. Prepared by:. Dr. Muntadher Abdulkareem Abdullah. M.B.Ch.B,CABM,FIBMS,FIBMS(GE.&HEP.). . introduction :. Drug toxicity should always be considered in the differential diagnosis of patients presenting with acute liver failure, jaundice or abnormal liver biochemistry.. DILI. Prepared by:. Dr. Muntadher Abdulkareem Abdullah. M.B.Ch.B,CABM,FIBMS,FIBMS(GE.&HEP.). Objectives :. At the end of this lecture, the student should know:. What is DILI?. What are the different pattern of DILI?.