PPT-Drug Metabolism

METABOLISM OR BIOTRANSFORMATION The conversion from one chemical form of a substance to another The term metabolism is commonly used probably because products of drug transformation are called . By Aidan Cross and Tom Grant. How many phases of drug . metabolism are there? (1 mark). 3 Phases. . What . is phase 1 of drug metabolism? (2). Provide a functional group (e.g. OH or NH. 2. ) to:. increase polarity of the drug. xenobiotic. . metabolism and . pharmacogenetics. George Howell III, . Ph.D. Sites of drug metabolism. Liver – responsible for the majority of drug metabolism. First pass metabolism. Kidney. GI. Lung. Natalie . Craythorne. 1. st. February 2013. Aims for today. To know what a drug is and how they are classified. To understand where drugs come from. Be able to explain the “lock and key” and induced fit hypotheses. Natalie . Craythorne. 27. th. September. . 2013. Aims for today. To know what a drug is and how they are classified. To understand where drugs come from. Be able to explain the “lock and key” and induced fit hypotheses. . Gastrointestinal and Hepatic Systems. . Regulation of Drug Transport, Absorption, Distribution, Excretion and Metabolism. Dennis Paul, Ph.D.. Department of Pharmacology. 504-568-4740. rwainf@lsuhsc.edu. Department of Pharmaceutics. . . Drug metabolism or Biotransformation is the major mechanism for elimination of drug from the body.. . It is the process by which the drug is chemically modified . Dr Shaheen. Delivered By . Dr Naser . Drug interactions- objectives. Discuss Pharmacokinetic interactions. List . Pharmacodynamic. interactions. Comment . on common Drug- Food interactions. Drug interactions. Isoenzymes. Presented by: Lahari . Paladugu. (. PharmD. 09-10). Presented on: February 7. ,. 2014. What is Genetic Polymorphism?. (1) . The existence . together of many forms . of DNA sequences . at . Tam Nguyen. November 25, 2014. CHEM4201. Introduction . What is . prodrug. ?. Why use . prodrugs. ?. Classification of . prodrugs. Applications of . prodrugs. Esters. Enalapril. Conclusion. References. Liver dysfunction and Drugs metabolism Dr V.Sebghatollahi Isfahan university of medical science Liver Functions: Metabolism – Carbohydrate, Fat & Protein Secretory – Bile acids, bile salts Factors affecting Drug Metabolism Pharmaceutical Medicinal Chemistry-I Dr. Bilal Al-Jaidi Assistant Professor in Medicinal Chemistry and Drug Design Faculty of Pharmacy, Philadelphia University-Jordan disease. Penny North-Lewis. Paediatric Liver Pharmacist. Leeds . Children’s Hospital. September 2019. Where is the liver?. What does the liver do?. Synthesis. . (e.g. albumin & clotting . factors, cholesterol). Moderator:- Dr . Ananya. . Chakraborty. Drug Metabolism . Dr Swaroop HS copyighted. 2. Introduction . History. Phases of Metabolism. Phase I Metabolism. Cytochrome. P family. Phase II Metabolism. First Pass Metabolism. west. Prepared By:. Rakiaa. Michael Saeed. Supervised by:. Asst. Prof. Dr. . Gulzar. I. Ibrahim. . Introduction . However, the term . xenobiotics. is very often used in the context of pollutants such as dioxins and polychlorinated biphenyls and their effect on the biota, because .