PPT-Cholesterol transport and uptake

Dr Carolyn K Suzuki 1 To compare and contrast the properties of apolipoprotein particles eg chylomicrons LDL HDL with respect to their composition metabolism and transport To distinguish the different biochemical pathways that can be potentially targeted pharmacologically to control plasma apolipoprotein levels and manage cardiovascular disease. High blood cholesterol is one of the major risk factors for heart disease A risk factor is a condition that increases your chance of getting a disease In fact the higher your blood cholesterol level the greater your risk for developing heart disease It is made in the liver and released into the bloodstream You can also get cholesterol from the food you eat It is important to get your cholesterol checked and learn how to manage your cholesterol The different types of cholesterol HDL Highdensity Learning outcome. Most cholesterol is synthesised by the liver from saturated fats in the diet. Cholesterol is a component of cell membranes and a precursor for steroid synthesis. High-density lipoprotein (HDL) transports excess cholesterol from the body cells to the liver for elimination. This prevents accumulation of cholesterol in the blood. Low-density lipoprotein (LDL) transports cholesterol to body cells. Most cells have LDL receptors that take LDL into the cell where it releases cholesterol. Once a cell has sufficient cholesterol a negative feedback system inhibits the synthesis of new LDL receptors and LDL circulates in the blood where it may deposit cholesterol in the arteries forming atheromas. A higher ratio of HDL to LDL will result in lower blood cholesterol and a reduced chance of atherosclerosis. . Topic 11 – Nutrient Dynamics. Nutrient Cycles and Budgets. Nutrient Transport , Spiraling and Uptake. Controls on Nutrient Dynamics. Measuring nutrient uptake. General definitions. Nutrient Cycle . Dr. Nikhat Siddiqi. 1. Overview. Cholesterol, the characteristic steroid alcohol of animal tissues, performs a number of essential functions in the body. . C. holesterol is a structural component of all cell membranes, modulating their fluidity, and, in specialized tissues, cholesterol is a precursor of bile acids, steroid hormones, and vitamin D. . Stephanie Seneff. Wise Traditions Workshop, London. Feb 9, 2014. Download These Slides. http://. people.csail.mit.edu. /. seneff. /London2014/SeneffHeartDisease2014.pptx. . ”If we all worked on the assumption that what is accepted as true is really true, there would be little hope of advance.. Discover the truth and the facts about The Oxidized Cholesterol Strategy™ PDF, eBook by Blue Heron Health News. Click \"SHARE\" and \"DOWNLOAD\" to read the document offline. Cholesterol is an essential lipid constituent of cell membranes. Cholesterol is a precursor of steroid hormones and of bile acids. Intermediates of cholesterol biosynthesis are required to make vitamin D and for posttranslational modification of membrane proteins. the transport both GABA into rat synaptosomes. They showed that DABA is competitive inhibitor inhibitor they showed that was par- tially inhibited They pointed out that but not but not rat cerebellum. Ray . Hreiche. (updated slides from . Mohana. . Ratnapalan. & Anna . Sher. ). (THANK YOU!!!). Learning Objectives . Explain the physiological functions of cholesterol in membrane stability.. Outline the synthesis of cholesterol from acetate.. Itzel . Vazquez-Vidal . and Peter J.H. . Jones. University . of Manitoba, Richardson Centre for Functional Foods and . Nutraceuticals.. 1. Principles of Nutrigenetics and . Nutrigenomics . Diet and Cardiovascular Disease. What are the current perspectives?. Prof. . Erik . Stroes. Academic Medical Centre. Amsterdam, The Netherlands. Is There a Therapeutic Need. . Beyond LDL Lowering ?. 1. Heart Protection Study Collaborative Group.. Peter Espenshade. Department of Cell Biology . Cellular Control of Metabolism. Jürgen Berger/Max Planck Institute. Cells require tight regulation of metabolism to maintain . homeostasis and viability.. Cardiovascular . Block. Dr. . Usman. . Ghani. Objectives. By the end of this lecture, the First Year students will be able to:. Correlate . the imbalance . in lipoprotein metabolism with the development of .