PPT-Cholesterol transport and uptake

Dr Carolyn K Suzuki 1 To compare and contrast the properties of apolipoprotein particles eg chylomicrons LDL HDL with respect to their composition metabolism and transport To distinguish the different biochemical pathways that can be potentially targeted pharmacologically to control plasma apolipoprotein levels and manage cardiovascular disease. AANUIIOU WELL ALANEIELOWINAUAE fats trans fats and cholesterol that includes a VAIEYOUI VEGEALEANA EEANLOW A dairy products AOILYWIEPEWEE OOELEANUOMEA IMALLVIILEAANOW AWAYEAAOOOUOEMEAEMOVEE skin from poultry 3UIUEMEALEOLOW MEAMAINIEO regular entrees Topic 11 – Nutrient Dynamics. Nutrient Cycles and Budgets. Nutrient Transport , Spiraling and Uptake. Controls on Nutrient Dynamics. Measuring nutrient uptake. General definitions. Nutrient Cycle . 5/e. Karen C. Timberlake. © 2016 Pearson Education, Inc.. 17.6 Steroids: Cholesterol, Bile Salts, and Steroid Hormones. High- and low-density lipoproteins transport cholesterol between the tissues and the liver.. Enrolled in a HIV incidence study in . Eldoret. Kenya.. . . Authors: . J. . Kipyego. , E. . Kaguiri. , G. . Mungai. , A. Komen, . J.Sawe. , . G.Kutwa. , JB . Ballidawa. , P. . Ayuo. , E. Were. . References: Garrett/Grisham . Biochemistry . (4. th. . ed. ). , . chs. . 23 and sections of 24. Berg, . Tymoczko. & . Stryer. . Biochemistry . (6ht . ed. )., sections of . Cholesterol is an essential lipid constituent of cell membranes. Cholesterol is a precursor of steroid hormones and of bile acids. Intermediates of cholesterol biosynthesis are required to make vitamin D and for posttranslational modification of membrane proteins. the transport both GABA into rat synaptosomes. They showed that DABA is competitive inhibitor inhibitor they showed that was par- tially inhibited They pointed out that but not but not rat cerebellum. Ray . Hreiche. (updated slides from . Mohana. . Ratnapalan. & Anna . Sher. ). (THANK YOU!!!). Learning Objectives . Explain the physiological functions of cholesterol in membrane stability.. Outline the synthesis of cholesterol from acetate.. Learning. . Objectives. The structure and composition of lipoproteins. Exogenous dietary fat transport vs. endogenous fat transport systems. Key enzymes involved in lipoprotein metabolism. Key cholesterol transporting lipoproteins and the relationship between their concentrations and the incidence of cardiovascular diseases. Dr.Deepa.G.S. Associate Professor. Dept.of. Physiology. Lipoproteins. Molecular complexes that consists of lipids and proteins. They function as transport vehicles for lipids in plasma. Lipoproteins-Structure. Cardiovascular . Block. Dr. . Usman. . Ghani. Objectives. By the end of this lecture, the First Year students will be able to:. Correlate . the imbalance . in lipoprotein metabolism with the development of . 2+. Cell Membrane . Fluid Mosaic Model . Cell membrane is thought to be both fluid and a mosaic of phospholipids, proteins and carbohydrates. . Fluid .  material is capable of flowing, changing shape, and shifting. Prof. Mamoun Ahram. Resources. This lecture. Lippincott’s Biochemistry, Ch. 15. What are lipids?. Lipids are heterogeneous, hydrophobic, compartmentalized in membranes, as droplets of triacylglycerol (TAG), or in lipoprotein (LP) particles or, or protein-bound. . Cholestero. l. Cholesterol is a fatty substance necessary for the proper functioning of the body, and it binds with lipoproteins, these proteins transport cholesterol to and from cells. The body needs cholesterol to make hormones, vitamin D, and to support the digestive process, the liver manufactures it in sufficient quantities it produces 80% .