PPT-Lipoproteins and Atheroscloresis

Cardiovascular Block Dr Usman Ghani Objectives By the end of this lecture the First Year students will be able to Correlate the imbalance in lipoprotein metabolism with the development of . 1. What is Cholesterol?. A waxy substance – technically a sterol (unsaturated steroid alcohol). 75% of your cholesterol is made in your liver, the rest is absorbed from food. Cholesterol travels in particles called lipoproteins: high-density lipoproteins (HDL) and low-Density Lipoproteins (LDL). Ceramide+carbohydrate. (. glucose,galactose,oligosacchride. side chain)=GLYCOLIPID. Cerebrosides:. contain a single moiety, principally galactose. Sulfatides:. sulfuric esters of galactocerebrosides. FromEgg. Yolk. Cholesterol. Is the most abundant . steroid. in the body.. Is a . waxy. substance found in all of the body cells. . Has . methyl. CH. 3. - groups, alkyl chain, and -OH attached to the steroid nucleus.. 5/e. Karen C. Timberlake. © 2016 Pearson Education, Inc.. 17.6 Steroids: Cholesterol, Bile Salts, and Steroid Hormones. High- and low-density lipoproteins transport cholesterol between the tissues and the liver.. Energy-Supplying. Nutrients. © 2017 Pearson Education, Inc.. The type of lipid found most abundantly . in foods . is. triglycerides.. b) . trans. . fatty acids.. phospholipids.. sterols.. © 2017 Pearson Education, Inc.. Assistant Professor. Pharmacy Practice Department. Definition. Hyperlipidemia, . hyperlipoproteinemia. , or . hyperlipidaemia. involves . abnormally elevated levels of any or all lipids and/or lipoproteins in the . Lipoproteins. are . types of . Compound Lipids /. Conjugated . Proteins. .. Lipoproteins . are . macromolecules. formed by aggregation of. . :. Lipids . (Neutral . and A. mphipathic ). Proteins. ( Apoprotein) in the human body.. Ray . Hreiche. (updated slides from . Mohana. . Ratnapalan. & Anna . Sher. ). (THANK YOU!!!). Learning Objectives . Explain the physiological functions of cholesterol in membrane stability.. Outline the synthesis of cholesterol from acetate.. .. Importance of lipoproteins formation. .        . 1- . Lipids are water insoluble substance and can not be trasported in an aqueous medium (blood plasma )..             . 2- in order to transport lipids between blood and different tissues they are associated with a protein to form water soluble complex . Dr.Deepa.G.S. Associate Professor. Dept.of. Physiology. Lipoproteins. Molecular complexes that consists of lipids and proteins. They function as transport vehicles for lipids in plasma. Lipoproteins-Structure. . Munther. . Lipids. Lipids are compounds that are insoluble in water, but soluble in an organic solvent (e.g., ether, benzene, acetone, chloroform). “lipid” composed mainly from C, H, O . • The main feature, in all lipids, is the large number of carbon-hydrogen bonds which makes them . lipoproteins. particles whose structure includes:. a . core. consisting of a droplet of triacylglycerols and/or cholesteryl esters. a . surface monolayer. of phospholipid, cholesterol, & specific proteins (apolipoproteins), e.g., B-100.. They bind with . soluble . protein. complexes . called. . lipoproteins. Lipids . can . be derived from food (exogenous) or synthesized. in the body (endogenous). The water-soluble (polar). groups of proteins, phospholipids and free cholesterol. Main lipids in the blood are the triglycerides and cholesterol.. Insoluble in the water.. Transport in the blood is via lipoproteins. Triglycerides. Glycerol with 3 attached fatty acids. Exogenous source : Dietary.