PPT-1 Lipoproteins Most lipids are transported in the blood as part of

lipoproteins particles whose structure includes a core consisting of a droplet of triacylglycerols andor cholesteryl esters a surface monolayer of phospholipid cholesterol amp specific proteins apolipoproteins eg B100. FromEgg. Yolk. Cholesterol. Is the most abundant . steroid. in the body.. Is a . waxy. substance found in all of the body cells. . Has . methyl. CH. 3. - groups, alkyl chain, and -OH attached to the steroid nucleus.. 5/e. Karen C. Timberlake. © 2016 Pearson Education, Inc.. 17.6 Steroids: Cholesterol, Bile Salts, and Steroid Hormones. High- and low-density lipoproteins transport cholesterol between the tissues and the liver.. References: Garrett/Grisham . Biochemistry . (4. th. . ed. ). , . chs. . 23 and sections of 24. Berg, . Tymoczko. & . Stryer. . Biochemistry . (6ht . ed. )., sections of . Lipoproteins. are . types of . Compound Lipids /. Conjugated . Proteins. .. Lipoproteins . are . macromolecules. formed by aggregation of. . :. Lipids . (Neutral . and A. mphipathic ). Proteins. ( Apoprotein) in the human body.. Plasma lipids . 200 . Lipoproteins . 201 . Fatty acids . 200 . Disorders of lipid metabolism . 207 . Cholesterol . 201 . Investigation of hyperlipidaemias . 214 . FATTY ACIDS . Lipids play a critical role in almost all aspects of . PSC 3110 – Fall semester 2008. Introduction. Definition: water insoluble compounds. Most lipids are fatty acids or ester of fatty acid. They are soluble in non-polar solvents such as petroleum ether, benzene, chloroform. Learning. . Objectives. The structure and composition of lipoproteins. Exogenous dietary fat transport vs. endogenous fat transport systems. Key enzymes involved in lipoprotein metabolism. Key cholesterol transporting lipoproteins and the relationship between their concentrations and the incidence of cardiovascular diseases. Glycrophospholipids degradation . Lipoproteins. G. L. Y. C. E. R. O. L. FATTY ACID. FATTY ACID. PHOSPHOACYLGLYCEROL. PHOSPHATE. ALCOHOL. Again this is the representation structure of glycerophospholipids.. .. Importance of lipoproteins formation. .        . 1- . Lipids are water insoluble substance and can not be trasported in an aqueous medium (blood plasma )..             . 2- in order to transport lipids between blood and different tissues they are associated with a protein to form water soluble complex . Outline O O Epidemiology O Clinical Aspects O Treatment O Effects of Exercise O Exercise Testing O Exercise Prescription O Summary and Conclusion O References What is Hyperlipidemia? Hyper - Lipid - E . Munther. . Lipids. Lipids are compounds that are insoluble in water, but soluble in an organic solvent (e.g., ether, benzene, acetone, chloroform). “lipid” composed mainly from C, H, O . • The main feature, in all lipids, is the large number of carbon-hydrogen bonds which makes them . They bind with . soluble . protein. complexes . called. . lipoproteins. Lipids . can . be derived from food (exogenous) or synthesized. in the body (endogenous). The water-soluble (polar). groups of proteins, phospholipids and free cholesterol. Main lipids in the blood are the triglycerides and cholesterol.. Insoluble in the water.. Transport in the blood is via lipoproteins. Triglycerides. Glycerol with 3 attached fatty acids. Exogenous source : Dietary. are a large and diverse group of naturally occurring organic compounds that share some general . properties. .. General Properties of Lipids. Insoluble . in water.. Soluble in non-polar organic solvents .