PPT-Lipoproteins Lipoproteins

Author : walsh | Published Date : 2022-04-07

Lipoproteins are types of Compound Lipids Conjugated Proteins Lipoproteins are macromolecules formed by aggregation of Lipids Neutral and A mphipathic

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Lipoproteins Lipoproteins: Transcript


Lipoproteins are types of Compound Lipids Conjugated Proteins Lipoproteins are macromolecules formed by aggregation of Lipids Neutral and A mphipathic Proteins Apoprotein in the human body. Learning outcome. Most cholesterol is synthesised by the liver from saturated fats in the diet. Cholesterol is a component of cell membranes and a precursor for steroid synthesis. High-density lipoprotein (HDL) transports excess cholesterol from the body cells to the liver for elimination. This prevents accumulation of cholesterol in the blood. Low-density lipoprotein (LDL) transports cholesterol to body cells. Most cells have LDL receptors that take LDL into the cell where it releases cholesterol. Once a cell has sufficient cholesterol a negative feedback system inhibits the synthesis of new LDL receptors and LDL circulates in the blood where it may deposit cholesterol in the arteries forming atheromas. A higher ratio of HDL to LDL will result in lower blood cholesterol and a reduced chance of atherosclerosis. . Ceramide+carbohydrate. (. glucose,galactose,oligosacchride. side chain)=GLYCOLIPID. Cerebrosides:. contain a single moiety, principally galactose. Sulfatides:. sulfuric esters of galactocerebrosides. : Learning Outcomes. State where cholesterol is synthesised. State the type . of . diet that can increase cholesterol levels in the blood. Give 2 reasons why cholesterol is important for cellular functions. Cholesterol. Is the most abundant . steroid. in the body.. Is a . waxy. substance found in all of the body cells. . Has . methyl. CH. 3. - groups, alkyl chain, and -OH attached to the steroid nucleus.. References: Garrett/Grisham . Biochemistry . (4. th. . ed. ). , . chs. . 23 and sections of 24. Berg, . Tymoczko. & . Stryer. . Biochemistry . (6ht . ed. )., sections of . Ray . Hreiche. (updated slides from . Mohana. . Ratnapalan. & Anna . Sher. ). (THANK YOU!!!). Learning Objectives . Explain the physiological functions of cholesterol in membrane stability.. Outline the synthesis of cholesterol from acetate.. Dr. . Haidar. F. Al-. Rubaye. . Lipids are an essential nutrient with diverse functions. Lipids, also known as fats and oils, are:. One of the 6 main groups of nutrients absorbed from the diet. A major source of energy that can be stored over long periods (body fat). Plasma lipids . 200 . Lipoproteins . 201 . Fatty acids . 200 . Disorders of lipid metabolism . 207 . Cholesterol . 201 . Investigation of hyperlipidaemias . 214 . FATTY ACIDS . Lipids play a critical role in almost all aspects of . Learning. . Objectives. The structure and composition of lipoproteins. Exogenous dietary fat transport vs. endogenous fat transport systems. Key enzymes involved in lipoprotein metabolism. Key cholesterol transporting lipoproteins and the relationship between their concentrations and the incidence of cardiovascular diseases. .. Importance of lipoproteins formation. .        . 1- . Lipids are water insoluble substance and can not be trasported in an aqueous medium (blood plasma )..             . 2- in order to transport lipids between blood and different tissues they are associated with a protein to form water soluble complex . CVS. 2018/2. ND. SEMESTER. • Four major groups of lipoproteins are recognized: Chylomicrons transport lipids resulting from digestion Lipid Metabolism and . absorption.Derived. from intestinal absorption of TG . . . very importance to . medical practice owing to its strong relations to . Arteriosclerosis and thus obesity, HTN, DM and . other abnormalities . . Good prognosis in the . manegment. of these conditions are . Lipoprotein Metabolism. Dr. . Usman. . Ghani. Objectives. By the end of this lecture, the First Year students will be able to:. Define and list the types, structure and composition of . lipoproteins. D.Pharm. , . Bpharm. , MSc ). O. utl. i. ne. Introduction. Definition of terminologies. Lipoprotein disorders. Types of dyslipidemia. Approaches to Management . Role. . and. . responsibili. ty of. .

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