PPT-Lipoproteins Lipoproteins

Lipoproteins are types of Compound Lipids Conjugated Proteins Lipoproteins are macromolecules formed by aggregation of Lipids Neutral and A mphipathic Proteins Apoprotein in the human body. : Learning Outcomes. State where cholesterol is synthesised. State the type . of . diet that can increase cholesterol levels in the blood. Give 2 reasons why cholesterol is important for cellular functions. 5/e. Karen C. Timberlake. © 2016 Pearson Education, Inc.. 17.6 Steroids: Cholesterol, Bile Salts, and Steroid Hormones. High- and low-density lipoproteins transport cholesterol between the tissues and the liver.. Ray . Hreiche. (updated slides from . Mohana. . Ratnapalan. & Anna . Sher. ). (THANK YOU!!!). Learning Objectives . Explain the physiological functions of cholesterol in membrane stability.. Outline the synthesis of cholesterol from acetate.. Plasma lipids . 200 . Lipoproteins . 201 . Fatty acids . 200 . Disorders of lipid metabolism . 207 . Cholesterol . 201 . Investigation of hyperlipidaemias . 214 . FATTY ACIDS . Lipids play a critical role in almost all aspects of . Learning. . Objectives. The structure and composition of lipoproteins. Exogenous dietary fat transport vs. endogenous fat transport systems. Key enzymes involved in lipoprotein metabolism. Key cholesterol transporting lipoproteins and the relationship between their concentrations and the incidence of cardiovascular diseases. Glycrophospholipids degradation . Lipoproteins. G. L. Y. C. E. R. O. L. FATTY ACID. FATTY ACID. PHOSPHOACYLGLYCEROL. PHOSPHATE. ALCOHOL. Again this is the representation structure of glycerophospholipids.. .. Importance of lipoproteins formation. .        . 1- . Lipids are water insoluble substance and can not be trasported in an aqueous medium (blood plasma )..             . 2- in order to transport lipids between blood and different tissues they are associated with a protein to form water soluble complex . CVS. 2018/2. ND. SEMESTER. • Four major groups of lipoproteins are recognized: Chylomicrons transport lipids resulting from digestion Lipid Metabolism and . absorption.Derived. from intestinal absorption of TG . . Dr.Deepa.G.S. Associate Professor. Dept.of. Physiology. Lipoproteins. Molecular complexes that consists of lipids and proteins. They function as transport vehicles for lipids in plasma. Lipoproteins-Structure. lipoproteins. particles whose structure includes:. a . core. consisting of a droplet of triacylglycerols and/or cholesteryl esters. a . surface monolayer. of phospholipid, cholesterol, & specific proteins (apolipoproteins), e.g., B-100.. Cardiovascular . Block. Dr. . Usman. . Ghani. Objectives. By the end of this lecture, the First Year students will be able to:. Correlate . the imbalance . in lipoprotein metabolism with the development of . D.Pharm. , . Bpharm. , MSc ). O. utl. i. ne. Introduction. Definition of terminologies. Lipoprotein disorders. Types of dyslipidemia. Approaches to Management . Role. . and. . responsibili. ty of. . They bind with . soluble . protein. complexes . called. . lipoproteins. Lipids . can . be derived from food (exogenous) or synthesized. in the body (endogenous). The water-soluble (polar). groups of proteins, phospholipids and free cholesterol. Main lipids in the blood are the triglycerides and cholesterol.. Insoluble in the water.. Transport in the blood is via lipoproteins. Triglycerides. Glycerol with 3 attached fatty acids. Exogenous source : Dietary.