PPT-Lipids III: Plasma Lipoproteins

Learning Objectives The structure and composition of lipoproteins Exogenous dietary fat transport vs endogenous fat transport systems Key enzymes involved in lipoprotein metabolism Key cholesterol transporting lipoproteins and the relationship between their concentrations and the incidence of cardiovascular diseases. Learning Objectives. Learn what a triglyceride is.. Learn what a fatty acid is.. Learn the structure of a . phospholipid. .. Learn how lipids are tested for.. What is a lipid?. Like most other biochemical substances, lipids contain . 5/e. Karen C. Timberlake. © 2016 Pearson Education, Inc.. 17.6 Steroids: Cholesterol, Bile Salts, and Steroid Hormones. High- and low-density lipoproteins transport cholesterol between the tissues and the liver.. References: Garrett/Grisham . Biochemistry . (4. th. . ed. ). , . chs. . 23 and sections of 24. Berg, . Tymoczko. & . Stryer. . Biochemistry . (6ht . ed. )., sections of . Lipoproteins. are . types of . Compound Lipids /. Conjugated . Proteins. .. Lipoproteins . are . macromolecules. formed by aggregation of. . :. Lipids . (Neutral . and A. mphipathic ). Proteins. ( Apoprotein) in the human body.. Plasma lipids . 200 . Lipoproteins . 201 . Fatty acids . 200 . Disorders of lipid metabolism . 207 . Cholesterol . 201 . Investigation of hyperlipidaemias . 214 . FATTY ACIDS . Lipids play a critical role in almost all aspects of . PSC 3110 – Fall semester 2008. Introduction. Definition: water insoluble compounds. Most lipids are fatty acids or ester of fatty acid. They are soluble in non-polar solvents such as petroleum ether, benzene, chloroform. Glycrophospholipids degradation . Lipoproteins. G. L. Y. C. E. R. O. L. FATTY ACID. FATTY ACID. PHOSPHOACYLGLYCEROL. PHOSPHATE. ALCOHOL. Again this is the representation structure of glycerophospholipids.. .. Importance of lipoproteins formation. .        . 1- . Lipids are water insoluble substance and can not be trasported in an aqueous medium (blood plasma )..             . 2- in order to transport lipids between blood and different tissues they are associated with a protein to form water soluble complex . . Munther. . Lipids. Lipids are compounds that are insoluble in water, but soluble in an organic solvent (e.g., ether, benzene, acetone, chloroform). “lipid” composed mainly from C, H, O . • The main feature, in all lipids, is the large number of carbon-hydrogen bonds which makes them . . very importance to . medical practice owing to its strong relations to . Arteriosclerosis and thus obesity, HTN, DM and . other abnormalities . . Good prognosis in the . manegment. of these conditions are . Prof. Mamoun Ahram. Resources. This lecture. Lippincott’s Biochemistry, Ch. 15. What are lipids?. Lipids are heterogeneous, hydrophobic, compartmentalized in membranes, as droplets of triacylglycerol (TAG), or in lipoprotein (LP) particles or, or protein-bound. . They bind with . soluble . protein. complexes . called. . lipoproteins. Lipids . can . be derived from food (exogenous) or synthesized. in the body (endogenous). The water-soluble (polar). groups of proteins, phospholipids and free cholesterol. Main lipids in the blood are the triglycerides and cholesterol.. Insoluble in the water.. Transport in the blood is via lipoproteins. Triglycerides. Glycerol with 3 attached fatty acids. Exogenous source : Dietary. are a large and diverse group of naturally occurring organic compounds that share some general . properties. .. General Properties of Lipids. Insoluble . in water.. Soluble in non-polar organic solvents .