PPT-Metabolism of lipids I: Absorption and transport

Prof Mamoun Ahram Resources This lecture Lippincotts Biochemistry Ch 15 What are lipids Lipids are heterogeneous hydrophobic compartmentalized in membranes as droplets of triacylglycerol TAG or in lipoprotein LP particles or or proteinbound . Lipids are….. It can be defined as . nonpolar. organic compound insoluble in polar solvent , but . soluble in organic solvents. such as benzene ,ether, . chloroform.. Biological role of lipids. :. Lipids. Essential . macronutrients. Provide . energy. Building blocks for cell membranes. Form many important hormones. Help transport fat-soluble nutrients. Contribute to flavor and texture of . food. Lipids are relatively insoluble in water.. They are soluble in . nonpolar. solvents such as chloroform , diethyl ether, acetone, benzene and ether.. The hydrophobic (water hating) nature of lipids is due to the predominance of hydrocarbon chain.(-CH2-CH2-CH2-) in their structure. Dr. Huda Hania. Lipid chemistry . Lipid chemistry . Definition . Fats and Oils (triglyceride) . Waxes. Steroids. Fat- soluble vitamins. Phospholipid. Mono- di glycerides . Lipid compounds including: . Lipids are non-polar. (hydrophobic) . organic compounds, insoluble in water, . soluble in organic . solvents (ether, acetone, . carbontetrachloride. ). . They contain carbon, hydrogen, and oxygen; sometimes nitrogen and phosphorus. . 3.4 What Are Lipids?. Lipids. are a diverse group of molecules that contain regions composed almost entirely of hydrogen and carbon. All lipids contain large chains of nonpolar hydrocarbons. Most lipids are therefore hydrophobic and water insoluble. Lipid chemistry . Lipid chemistry . Definition . Fats and Oils (triglyceride) . Waxes. Steroids. Fat- soluble vitamins. Phospholipid. Mono- di glycerides . Lipid compounds including: . Classification of Lipids. The anti-inflammatory properties of lipids extracted from Omani camel milk Raya Hamdan Salim Al-Nasseri , M.Sc * Morris Keith , Director of study, Cardiff school of Health Sciences, Cardiff Metropolitan University, Wales, UK. nonpolar. organic compound insoluble in polar solvent , but . soluble in organic solvents. such as benzene ,ether, chloroform.. Biological role of lipids. :. Lipids are found naturally in all living organisms.. Cholesterol. Rich in hydrocarbon. Polar group (usually small). Oleic acid. Lipids serve a wide variety of functions. Vitamin K. Surfactants. Protection. Membrane. components. Insulation. Energy storage. BIOMEDICAL IMPORTANCE. Besides water, the diet must provide metabolic fuels (mainly carbohydrates and lipids), protein (for growth and turnover of tissue proteins), fiber (for roughage), minerals (elements with specific metabolic functions), and vitamins and essential fatty acids (organic compounds needed in small amounts for essential metabolic and physiologic functions). . Lipids & Membranes. Diversity of Lipids. Stored forms of energy. derivatives of fatty acids. oxidation is highly exergonic. Structure. h. igh heat capacity. mechanical protection (absorb shocks). Absorption of drugs. Definitions –. . Absorption of drugs can be defined as – . a process of movement of drug from the site of administration to site of measurement i.e. systemic circulation, in it’s unchanged form.. UNIVERSITY . INSTITUTE OF PHARMACY. ,. CSJM University, . KANPUR. Absorption from the . gastrointestinal tract (GIT) is . governed by factors such as. :. S. urface area for absorption. Blood flow to the site of absorption.