PPT-DRUG ABSORPTION THROUGH VARIOUS ROUTES OF ADMINISTRATION

UNIVERSITY INSTITUTE OF PHARMACY CSJM University KANPUR Absorption from the gastrointestinal tract GIT is governed by factors such as S urface area for absorption Blood flow to the site of absorption. A SEMINAR ON. . by. . V. Sandeep Kumar. . M.Pharmacy, I Sem.. Department of Pharmaceutics. University College Of Pharmaceutical Sciences. Natalie . Craythorne. 1. st. February 2013. Aims for today. To know what a drug is and how they are classified. To understand where drugs come from. Be able to explain the “lock and key” and induced fit hypotheses. Natalie . Craythorne. 27. th. September. . 2013. Aims for today. To know what a drug is and how they are classified. To understand where drugs come from. Be able to explain the “lock and key” and induced fit hypotheses. Mental picture of . what’s happening . inside…. … really might help.. Drug action (effects). Proportional to concentration at site of action. Concentration predicts better than dose. General Rules. Routes of administration. Chapter Topics. Routes of administration. Oral route of administration. Transmucosal. route of administration. Topical route of administration. Inhalation route of administration. 2. Transdermal drug delivery systems (TDDSs) facilitate the passage of therapeutic quantities of drug substances through the skin and into the general circulation for their systemic effects. . In 1965, Stoughton first conceived of the . Alfred L. George, Jr., M.D.. Department of Pharmacology. al.george@northwestern.edu. Drug Absorption. Absorption refers to the transfer of a drug from its site of administration to the systemic circulation.. Dr. Jwan Mohammed. Oral route . Parenteral route. Intravenous. Intramuscular. Subcutaneous. Transdermal route. Rectal route . Pulmonary route . Oral route of administration. The oral route of administration is the most convenient route for drug administration because of low production cost, better suitability for self administration, higher level of patient safety and better patient . Alfred L. George, Jr., M.D.. Department of Pharmacology. al.george@northwestern.edu. Drug Absorption. Absorption refers to the transfer of a drug from its site of administration to the systemic circulation.. Pharmacokinetics and . Pharmacodynamics. of Peptide and Protein Drugs . The central paradigm of clinical pharmacology: The dose-concentration-effect relationship. Dose . pharmacokinetics. concentration. and Protein Drugs . The central paradigm(. نموذج. ). of clinical pharmacology: The dose-concentration-effect relationship. Dose (mg/day) . pharmacokinetics. Concentration. (mg/l). Efficacy . Toxicity. Alternative routes of administration. Alternative Route of Administration. . Parenteral administration. . has disadvantages (needles, sterility, injection skill) compared to other possible routes.. Absorption of drugs. Definitions –. . Absorption of drugs can be defined as – . a process of movement of drug from the site of administration to site of measurement i.e. systemic circulation, in it’s unchanged form.. Sterile products are dosage forms of therapeutic agents that are free of viable microorganisms.. Principally, these include parenteral, ophthalmic, and irrigating preparations.. Of these, parenteral products are unique among dosage forms of drugs .