PPT-Drug Absorption and Distribution

Alfred L George Jr MD Department of Pharmacology algeorgenorthwesternedu Drug Absorption Absorption refers to the transfer of a drug from its site of administration to the systemic circulation. Andrew Rouff and Kyle Chau. The Basics. . wavelength= (λ) . original intensity= . Ι. o . . sample slab thickness= dl. Final intensity= . I. f. ε. ’. = molar extinction coefficient. -d. I. = Cε. Basic properties of molecular absorption (how & why). Absorption Spectrum. Absorption coefficient and pressure broadening. Transmission. Application: basis . for estimating column CO. 2. and . O. By: Matt Hanley. Digestive Processes. GI tract. Small Intestine. Large Intestine. Absorption. GI Tract. Mixes food with gastric acid. Digests proteins. HCL acid kills pathogens. Mucus protects inner lining. Lecture #16. Factors Determining Absorption of Oral Dosage Forms. Dosage Form Characteristics. Active Pharmaceutical Ingredient (API) Properties. GI Tract Physiology. GI Tract Abnormalities/Disease. Dosage Form Characteristics. Mental picture of . what’s happening . inside…. … really might help.. Drug action (effects). Proportional to concentration at site of action. Concentration predicts better than dose. General Rules. 2. Transdermal drug delivery systems (TDDSs) facilitate the passage of therapeutic quantities of drug substances through the skin and into the general circulation for their systemic effects. . In 1965, Stoughton first conceived of the . Water, Electrolytes . and. . Carbohydrates. Gregory J. Bagby, PhD. Rozas Professor of Physiology. CSRB . Rm. 3B9/310. gbagby@lsuhsc.edu. 504-568-6188. GI PHYSIOLOGY. Text for Lectures . Raff and Levitzky. Dr. Jwan Mohammed. Oral route . Parenteral route. Intravenous. Intramuscular. Subcutaneous. Transdermal route. Rectal route . Pulmonary route . Oral route of administration. The oral route of administration is the most convenient route for drug administration because of low production cost, better suitability for self administration, higher level of patient safety and better patient . What’s That Sound?: A Comparison of Sound Absorption of Different Commercial Flooring Which material has the most substantial absorption when exposed to various sound variations? Of the variables that are to be tested, carpet will be the one to have the greater absorption due to its characteristics of not being solidified by its padding, softness, and flexibility. Kris Gill. What is Sound Absorption?. . Any technique used to manage the reflection of sound off of a surface. causing sound energy to be dissipated.. Absorption. Reflection. Diffusion. Two types of sound absorption. . Regulation of Drug Transport, Absorption, Distribution, Excretion and Metabolism. Dennis Paul, Ph.D.. Department of Pharmacology. 504-568-4740. rwainf@lsuhsc.edu. Principles of Pharmacology. Common processes and mechanisms whereby: . and Protein Drugs . The central paradigm(. نموذج. ). of clinical pharmacology: The dose-concentration-effect relationship. Dose (mg/day) . pharmacokinetics. Concentration. (mg/l). Efficacy . Toxicity. BIOMEDICAL IMPORTANCE. Besides water, the diet must provide metabolic fuels (mainly carbohydrates and lipids), protein (for growth and turnover of tissue proteins), fiber (for roughage), minerals (elements with specific metabolic functions), and vitamins and essential fatty acids (organic compounds needed in small amounts for essential metabolic and physiologic functions). . UNIVERSITY . INSTITUTE OF PHARMACY. ,. CSJM University, . KANPUR. Absorption from the . gastrointestinal tract (GIT) is . governed by factors such as. :. S. urface area for absorption. Blood flow to the site of absorption.