PPT-Pharmacokinetics (Drug disposition)

Mental picture of whats happening inside really might help Drug action effects Proportional to concentration at site of action Concentration predicts better than dose General Rules. & THERAPEUTICS . ESSENTIAL DRUG LIST . Alexandra Burke-Smith. 1. Drugs and the Autonomic Nervous System . Overview of the ANS . Sympathetic NS = “fight or flight”, Parasympathetic NS = “rest + digest”. The Absorption,. Distribution, and. Excretion of Drugs. METABOLISM:. "Drug biotransformation, generally into more polar compounds readily excreted from the body through urine or feces.“ . Drug metabolism. Properties: . Optimizing Pharmacokinetics and Safety During Drug . Discovery. ACS Short Course. Li Di and Edward H. Kerns. Introduction to Drug-Like Properties. Few research compounds will become drugs because they lack sufficient pharmacokinetics (PK) and safety. Jessica Tagerman, . PharmD. , . RPh. Pharmacokinetics & pharmacodynamics. Pharmacodynamics: What the drug does to the body. Pharmacokinetics: What the body does to the drug. pharmacodynamics. “What the drug does to the body”. Pediatric Patients. All patients younger than16 years. Respond differently to drugs than the rest of the population. More sensitive . to drugs than other patients are. Show . greater individual . variation. BW733. October 1, 2013. Pharmacokinetics . WebQuest. 1. http://. www.speedlighter.ca/2011/12/25/why-i-shoot-stills/courtney-craig-photo-by-michael-willems. /. Overview. Introduction. Absorption. IV, . of obstetric anesthesia . Dr SPS. 10/4/2015. 1. Dr. S. Parthasarathy MD., DA., DNB, . MD (. Acu. ), Dip. . Diab. . DCA, . Dip. Software statistics, . PhD (physiology) FICA . Mahatma Gandhi Medical College and Research Institute, . Pharmacokinetics and . Pharmacodynamics. of Peptide and Protein Drugs . The central paradigm of clinical pharmacology: The dose-concentration-effect relationship. Dose . pharmacokinetics. concentration. NUR 652. Mikael D. Jones, Pharm.D., BCPS. College of Nursing. College of Pharmacy. Introduction. Pharmacology. The study of drugs and their effects in and on the body. 3 Branches of Study in Pharmacology. Pharmacokinetics of drugs . (ADME). . Are studies of . . A. bsorption. . D. istribution. . M. etabolism . . E. xcretion of drugs. Importance of PK studies. Patients may suffer:. Toxic drugs may accumulate. and Protein Drugs . The central paradigm(. نموذج. ). of clinical pharmacology: The dose-concentration-effect relationship. Dose (mg/day) . pharmacokinetics. Concentration. (mg/l). Efficacy . Toxicity. Pharmacokinetics. Dosage adjustment in renal impairment. Dialysis removal of drugs. Ideal drug for a renal patient. Non-renal excretion. No side effects. Active drug. No renally excreted metabolites. The . use of drugs to treat psychiatric disorders is often the foundation for a successful treatment approach that can also include other types of intervention such as psychotherapy and behavior therapy. . Alobaidy. Reference text. Shargel. L., Yu AB. Applied Biopharmaceutics and Pharmacokinetics. Introduction. The . physicochemical characteristics of the active pharmaceutical . ingredient, . the dosage form .