PPT-Pharmacokinetics & Drug Dosing

Pharmacokinetics Dosage adjustment in renal impairment Dialysis removal of drugs Ideal drug for a renal patient Nonrenal excretion No side effects Active drug No renally excreted metabolites. . Dosing Advisor. 7/9/2012/. hf. Initial dose recommendation based on height, weight, and . creatinine. clearance (calculated from . SCr. ). Obesity factored into dose calculation. Serum . creatinine. Nancy Clark, . M.Ed. , . Director Medical Informatics Education. , M.D.. Informatics Curriculum Director Regional Campus . 2016. 1. Objectives. Find the Drug Reference Library web page. Errors. Implications for Disaster Medicine . William Fales, MD, FACEP. Michigan State University Kalamazoo Center for Medical Studies. 5. th. District Medical Response Coalition. Kalamazoo County Medical Control Authority. Geriatric Patients. Disproportionately high prescription drug use exists in the elderly.. 12% of Americans are age 65 years or older.. This 12% consumes 31% of prescribed drugs.. Geriatric patients experience more adverse drug reactions and drug-drug interactions than younger patients do.. Michael Palladini, RPh MBA CAC. info@drugsofabuse.net. “BUNAVAIL . is the first and only FDA-approved buccal film formulation of . buprenorphine. and naloxone and will compete in the $1.7 billion and growing U.S. opioid dependence market. Mental picture of . what’s happening . inside…. … really might help.. Drug action (effects). Proportional to concentration at site of action. Concentration predicts better than dose. General Rules. Pediatric Patients. All patients younger than16 years. Respond differently to drugs than the rest of the population. More sensitive . to drugs than other patients are. Show . greater individual . variation. Definitions: Seizure, Epilepsy, Epilepsy Syndrome Goals of Medical Therapy Individualizing AED Selection Comorbidities AED Mechanisms of Action Effectiveness of AED Combination Therapy Based on Mechanism of Action based on 3-month 13-week dosing intervals with the flexibility of dosing between weeks 11 and 13GIVENDUEJan1Mar19-Apr2Jan2Mar20-Apr3Jan3Mar21-Apr4Jan4Mar22-Apr5Jan5Mar23-Apr6Jan6Mar24-Apr7Jan7Mar25-Ap CRRT BackgroundWhena patient is initiated on CRRT antimicrobial therapy often requires adjustment to ensure adequate drug concentrations are achievedCVVHDremoves solutes including drugs via diffusion . Alfonso Iorio, on behalf of the working group. DISCLOSURES. Financial conflicts of interests. McMaster University has received . funds for research. and . service agreements . from Bayer, . Baxalta. The . use of drugs to treat psychiatric disorders is often the foundation for a successful treatment approach that can also include other types of intervention such as psychotherapy and behavior therapy. . Joseph McGraw, Pharm.D., M.P.H., Ph.D.. Associate Professor of Pharmaceutical Sciences . CUW School of Pharmacy . President and Chief Scientific Officer . Persotype. DX LLC. Background. Ph.D.-Biopharmaceutical Sciences. . Created by: Andrew . Fratoni. , . PharmD. IV Aminoglycosides. Gentamicin. Tobramycin*. Amikacin*. *Restricted Antibiotics. Aminoglycoside Drug . Class Principles. Good bactericidal activity against gram negative organisms.