PPT-LIPOPROTEINS,KETOGENESIS

DrDeepaGS Associate Professor Deptof Physiology Lipoproteins Molecular complexes that consists of lipids and proteins They function as transport vehicles for lipids in plasma LipoproteinsStructure. Learning outcome. Most cholesterol is synthesised by the liver from saturated fats in the diet. Cholesterol is a component of cell membranes and a precursor for steroid synthesis. High-density lipoprotein (HDL) transports excess cholesterol from the body cells to the liver for elimination. This prevents accumulation of cholesterol in the blood. Low-density lipoprotein (LDL) transports cholesterol to body cells. Most cells have LDL receptors that take LDL into the cell where it releases cholesterol. Once a cell has sufficient cholesterol a negative feedback system inhibits the synthesis of new LDL receptors and LDL circulates in the blood where it may deposit cholesterol in the arteries forming atheromas. A higher ratio of HDL to LDL will result in lower blood cholesterol and a reduced chance of atherosclerosis. . FromEgg. Yolk. Cholesterol. Is the most abundant . steroid. in the body.. Is a . waxy. substance found in all of the body cells. . Has . methyl. CH. 3. - groups, alkyl chain, and -OH attached to the steroid nucleus.. : Learning Outcomes. State where cholesterol is synthesised. State the type . of . diet that can increase cholesterol levels in the blood. Give 2 reasons why cholesterol is important for cellular functions. 5/e. Karen C. Timberlake. © 2016 Pearson Education, Inc.. 17.6 Steroids: Cholesterol, Bile Salts, and Steroid Hormones. High- and low-density lipoproteins transport cholesterol between the tissues and the liver.. References: Garrett/Grisham . Biochemistry . (4. th. . ed. ). , . chs. . 23 and sections of 24. Berg, . Tymoczko. & . Stryer. . Biochemistry . (6ht . ed. )., sections of . Lipoproteins. are . types of . Compound Lipids /. Conjugated . Proteins. .. Lipoproteins . are . macromolecules. formed by aggregation of. . :. Lipids . (Neutral . and A. mphipathic ). Proteins. ( Apoprotein) in the human body.. Ray . Hreiche. (updated slides from . Mohana. . Ratnapalan. & Anna . Sher. ). (THANK YOU!!!). Learning Objectives . Explain the physiological functions of cholesterol in membrane stability.. Outline the synthesis of cholesterol from acetate.. . Meenakshi. . . Garg. . University . of Delhi, . India. . Introduction. India is just behind US and China in global hazard list of top 10 countries with highest number of obese people. A country where 270 million people live below the 'poverty line', obesity seems to be a distant issue, meant for the rich kids of first world.. Dr. . Haidar. F. Al-. Rubaye. . Lipids are an essential nutrient with diverse functions. Lipids, also known as fats and oils, are:. One of the 6 main groups of nutrients absorbed from the diet. A major source of energy that can be stored over long periods (body fat). Plasma lipids . 200 . Lipoproteins . 201 . Fatty acids . 200 . Disorders of lipid metabolism . 207 . Cholesterol . 201 . Investigation of hyperlipidaemias . 214 . FATTY ACIDS . Lipids play a critical role in almost all aspects of . ketones. are present in body fluids in elevated . concentrations. K. etone. bodies are . acetoacetic. . acid, . beta-. hydroxybutyric. acid and acetone. Ketosis is frequently associated with . ketoacidosis. Outline O O Epidemiology O Clinical Aspects O Treatment O Effects of Exercise O Exercise Testing O Exercise Prescription O Summary and Conclusion O References What is Hyperlipidemia? Hyper - Lipid - E D.Pharm. , . Bpharm. , MSc ). O. utl. i. ne. Introduction. Definition of terminologies. Lipoprotein disorders. Types of dyslipidemia. Approaches to Management . Role. . and. . responsibili. ty of. . Main lipids in the blood are the triglycerides and cholesterol.. Insoluble in the water.. Transport in the blood is via lipoproteins. Triglycerides. Glycerol with 3 attached fatty acids. Exogenous source : Dietary.