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Slide1
Non-steroidal anti-inflammatory drugs for low back pain (acute)
Roelofs et al (2008)
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Slide2Non-steroidal anti-inflammatory drugs
Roelofs et al (2008)Overview of the study
Objectives To assess the effects of NSAIDs and COX-2 inhibitors in the treatment of non- specific low-back pain and to assess which type of NSAID is most effectiveMethods Evidence current up to 30 June 2007 Interventions: One or more types of NSAIDs
Participants: Adults (18
years or older
) treated for non-specific low-back pain
with or without sciatica
Outcomes
Primary: Pain intensity, global measure, back-specific functional status, return-to-work,
adverse events
Secondary: Physiological outcomes, functional status
Slide365 trials (11,237 participants)
Results & Conclusions
Interventions
Evidence
Quality
of evidence
NSAIDs
As
effective
as paracetamol
for
acute low-back pain for pain relief and global improvementModerateNo more effective than other drugs for acute LBPModerateNo more effective than physiotherapy or spinal manipulation for pain relief in acute low-back painModerateVarious types of NSAIDs including COX-2 NSAIDs equally effective for acute LBPModerate
Non-steroidal anti-inflammatory drugs Roelofs et al (2013)
Adverse events:
There is no clear difference in the reported number or severity of
adverse events between the different types of NSAIDs
Evidence suggests that NSAIDs are effective for short-term symptomatic relief in patients with acute low-back pain without sciatica, yet no specific type of NSAID is clearly more effective than others