PPT-Epigenetics of Atherosclerosis

Yongmgei Liu MD PhD FAHA Wake Forest School of Medicine Claudia E Korcarz DVM Atherosclerosis Imaging Research Program University Wisconsin MESA Epigenomics Study in . Mike Clark, M.D.. Terms. Arteriosclerosis – hardening of the arteries. Atherosclerosis – a form of arteriosclerosis. Venosclerosis. Arteriolosclerosis . Step One of Atherosclerosis. Endothelium injured. :. DNA . methylation. II. DNA . methylation. in plants (Ch9). Differences between plants and animals. Auxotroph . vs. . heterotroph. Sessile . vs. . mobile. Motionless and rigid . vs. . migrating and flexible cells. . Samudra. K. . Wijeratne. , Ph.D.. Dept. of Nutrition and Health Sciences, UNL. Processes in . Epigenetics. The . study of heritable changes in gene expression or cellular phenotype caused by mechanisms other than changes in the underlying DNA . How do we make this work?. Dr. Paul S. Anderson. NYANP. 2017. (c) PS Anderson - www.ConsultDrA.com - 2017. 1. Dr. Anderson - Disclosures. Ownership interest in:. • Advanced Medical Therapies Clinic Seattle, WA. What is Atherosclerosis. Plaque builds up on artery walls causing the body to be deprived of oxygen.. Plague is made up of many substances from the blood.. Atherosclerosis is one of the main causes for many heart problems which is why it is sometime referred to as heart disease. . http://www.knowabouthealth.com/wp-content/uploads/2010/06/mcdonalds_.jpg. http://emilyscarenhealth.wordpress.com/2011/10/04/attention-a-must-read-for-smokers/. Can “. nuture. ” change “nature” ?. Terms. Arteriosclerosis – hardening of the arteries. Atherosclerosis – a form of arteriosclerosis. Venosclerosis. Arteriolosclerosis . Step One of Atherosclerosis. Endothelium injured. The tunica interna is injured in some way by bloodborne chemicals, hypertension, components of cigarette smoke or viral or bacterial infections. Almost any type of chronic infection – including periodontal disease can cause the damage.. Overview. Buildup of plaque in arteries. Causes hardening of the arteries. Restricts blood flow. Atherosclerosis in the heart is called . Coronary Artery Disease. Sudden plaque rupture or clotting can cause the heart muscle to die.. Overview. Buildup of plaque in arteries. Causes hardening of the arteries. Restricts blood flow. Atherosclerosis in the heart is called . Coronary Artery Disease. Sudden plaque rupture or clotting can cause the heart muscle to die.. Thomboplastin. , Thrombin, . Prothrombin. , Fibrin, Fibrinogen. What do you know about atherosclerosis?. Atherosclerosis. L/O – What causes atherosclerosis?. ALL Describe the term Atherosclerosis. MOST Describe the steps that lead to Atherosclerosis. nuture. ; how our environment talks to us, sometimes forever.. Nessa. Carey, The Epigenetics Revolution (2012). The epigenetics revolution is underway.. Nessa. Carey, The Epigenetics Revolution (2012). Epigenetics comprises (hereditary) changes in gene expression without altering the DNA sequence . Epigenetics is a biological subdiscipline that deals with questions of development, heredity, gene regulation and evolution . ‘Epi’: On top of. . Definition:. The . study of changes in organisms caused by modification of gene expression rather than alteration of the genetic code itself.. DNA. How many cell types are in the human body?. A cross-sectional study. 595 gout patients. T. ophi-free group (76.47%) and the tophi group (23.53%). Gout patients. Interaction with IR. Hepatic IR. (. HOMA index. ) . Peripheral IR. (. Gutt index.