Thomboplastin Thrombin Prothrombin Fibrin Fibrinogen What do you know about atherosclerosis Atherosclerosis LO What causes atherosclerosis ALL Describe the term Atherosclerosis MOST Describe the steps that lead to Atherosclerosis ID: 909928
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Slide1
Keywords – Atheroma, Plaque, Atherosclerosis, Thomboplastin, Thrombin, Prothrombin, Fibrin, Fibrinogen
What do you know about atherosclerosis?
Atherosclerosis
L/O – What causes atherosclerosis?
ALL Describe the term Atherosclerosis
MOST Describe the steps that lead to Atherosclerosis
SOME Explain how blood clots form
Slide2AtherosclerosisAtherosclerosis is the disease process that leads to coronary heart disease and strokesIn Atherosclerosis……fatty deposits narrow or block an artery or…increases the chance of a blood clot (Thrombosis) forming
ALL Describe the term Atherosclerosis
MOST Describe the steps that lead to
AtherosclerosisSOME Explain how blood clots form
Keywords – Atheroma, Plaque, Atherosclerosis, Thomboplastin, Thrombin, Prothrombin, Fibrin, FibrinogenL/O – What causes atherosclerosis?
Slide3Heart AttackThe technical name for a heart attack is a……myocardial infarctionThis occurs when a blood clot breaks free and lodges in the capillaries in the heart
This causes the flow of blood to be restrictedThe muscle tissue in the heart is the starved of oxygen and glucoseThe muscle cramps due to anaerobic respiration and eventually dies!
ALL Describe the term Atherosclerosis
MOST Describe the steps that lead to
AtherosclerosisSOME Explain how blood clots formKeywords – Atheroma, Plaque, Atherosclerosis, Thomboplastin, Thrombin, Prothrombin, Fibrin, FibrinogenL/O – What causes atherosclerosis?
Slide4StrokeStrokes occur for similar reasons to heart attacksA blood clot lodges in capillaries in the brain cutting of bloodIt can also cause a high pressure to build behind the clotThis causes a capillary to burst causing internal bleeding called an aneurism
ALL Describe the term Atherosclerosis
MOST Describe the steps that lead to
Atherosclerosis
SOME Explain how blood clots formKeywords – Atheroma, Plaque, Atherosclerosis, Thomboplastin, Thrombin, Prothrombin, Fibrin, FibrinogenL/O – What causes atherosclerosis?
Slide5Sequence of AtherosclerosisThere is an inflammatory response in the arterial wallWhite blood cells accumulate in the arterial wallCholesterol accumulates at the site of the inflammation
This builds up to form an Atheroma
ALL Describe the term Atherosclerosis
MOST Describe the steps that lead to Atherosclerosis
SOME Explain how blood clots formKeywords – Atheroma, Plaque, Atherosclerosis, Thomboplastin, Thrombin, Prothrombin, Fibrin, FibrinogenL/O – What causes atherosclerosis?
Slide6Sequence of AtherosclerosisCalcium salts and fibrous tissue build up on the atheroma causing a hard plaque to form
The arterial wall hardens and looses its elasticity
ALL Describe the term Atherosclerosis
MOST Describe the steps that lead to Atherosclerosis
SOME Explain how blood clots formKeywords – Atheroma, Plaque, Atherosclerosis, Thomboplastin, Thrombin, Prothrombin, Fibrin, FibrinogenL/O – What causes atherosclerosis?
Slide7Sequence of AtherosclerosisThe plaques cause the artery to narrowBlood pressure rises which increases the rate of precipitation of calciumThis is a positive feedback loop
At this stage a person may suffer from Angina
ALL Describe the term Atherosclerosis
MOST Describe the steps that lead to Atherosclerosis
SOME Explain how blood clots formKeywords – Atheroma, Plaque, Atherosclerosis, Thomboplastin, Thrombin, Prothrombin, Fibrin, FibrinogenL/O – What causes atherosclerosis?
Slide8ALL Describe the term AtherosclerosisMOST Describe the steps that lead to Atherosclerosis
SOME Explain how blood clots form
Keywords – Atheroma, Plaque, Atherosclerosis,
Thomboplastin, Thrombin, Prothrombin, Fibrin, Fibrinogen
L/O – What causes atherosclerosis?
Slide9ALL Describe the term AtherosclerosisMOST Describe the steps that lead to Atherosclerosis
SOME Explain how blood clots form
Slide10ALL Describe the term AtherosclerosisMOST Describe the steps that lead to Atherosclerosis
SOME Explain how blood clots form
Slide11Blood ClotsAs the blood flow slows around the plaque……platelets stick to exposed collagen in the plaqueThey release ADP which causes more platelets to stick
This triggers a series of biochemical reactions in the blood causing the blood to clot
ALL Describe the term Atherosclerosis
MOST Describe the steps that lead to Atherosclerosis
SOME Explain how blood clots formKeywords – Atheroma, Plaque, Atherosclerosis, Thomboplastin, Thrombin, Prothrombin, Fibrin, FibrinogenL/O – What causes atherosclerosis?
Slide12ALL Describe the term AtherosclerosisMOST Describe the steps that lead to Atherosclerosis
SOME Explain how blood clots form
Prothrombin
Insoluble
FibrinSoluble FibrinogenThromboplastin – released from damaged tissue and plateletsCalcium ions and Vitamin K
Thrombin
Slide13ALL Describe the term AtherosclerosisMOST Describe the steps that lead to Atherosclerosis
SOME Explain how blood clots form
Slide14Why do only arteries get atherosclerosisDue to the fast high pressure flow in arteries there is a greater chance of damage occurring to arterial walls
ALL Describe the term Atherosclerosis
MOST Describe the steps that lead to Atherosclerosis
SOME Explain how blood clots form
Keywords – Atheroma, Plaque, Atherosclerosis, Thomboplastin, Thrombin, Prothrombin, Fibrin, FibrinogenL/O – What causes atherosclerosis?
Slide15Design a website for NHS Direct to describe what Atherosclerosis is. Include images and links to other sites and information.ALL Include definitions and a list of symptoms
MOST Write a sequence of steps for atherosclerosisSOME Describe the process of blood clotting and the issues that these blood clots can cause
ALL Describe the term Atherosclerosis
MOST Describe the steps that lead to
AtherosclerosisSOME Explain how blood clots formKeywords – Atheroma, Plaque, Atherosclerosis, Thomboplastin, Thrombin, Prothrombin, Fibrin, FibrinogenL/O – What causes atherosclerosis?