PPT-Wet Granulation Scale-up Experiments

Scaleup Approach with Dimensional Numbers 2 The effect of process parameter ie impeller speed liquid addition rate on the process and thus on granule characteristics are evaluated based on mechanistic understanding. Comparing Granulation Methods Figure 3: Fluid bed top spray granulator GRANULATIONSingle Pot - A mixer/granulator that dries granules in the same equipment without discharging is commonly called a Sin Bayani. . Cardenas, . Kirsten . Chojnicki, . Chang Da, David . DiCarlo. , . Eric . Guiltinan. , . Susan . Hovorka. , Chun Huh, Keith Johnston,. . Ijung. . Kim, . Prasanna. Krishnamurthy, . Alec Kucala, . Intermediate batch scale . Manufacture. Objectives of scale up. Formulation related: Identification & control of critical components, other variables.. Equipment related: Identification & control of critical parameters & operations. Dry granulation. Granulation. is the process in which the . primary powder particles . are made to . adhere to form large multi –entities . called granules.. Primary reasons for granulation: . Secondary reasons for granulation. The wet granulation technique uses the same preparatory and finishing steps of direct compression and dry granulation (. dry. . screening and mixing. ); it also involve additional steps of . wet massing, wet screening and drying.. Dry methods. Direct compression. Dry granulation. Wet methods. Wet granulation. Advantages. - Economy. - Machine: fewer manufacturing steps and pieces of equipment. - Labor: reduce labor costs. - Less process validation. In order to optimize this process and maximize desirability for formulations comprising of certain spray-dried amorphous dispersions, we recommend using:. Mannitol. as a filler and a ratio of brittle: ductile components . Lab 3 t To prevent segregation. To improve flow properties of the mix. To improve compaction characteristics of the mix. Dry granulation Granulation is the process in which the primary powder partic Wet Granulation The wet granulation technique uses the same preparatory and finishing steps of direct compression and dry granulation ( dry screening and mixing ) ; it also involve additional steps of MCC Starch Lactose Superdisintegants Wet granulation of milled Wet granulation of milled lactose Summary Lactose is commonly wet granulated with microcrystalline cellulose in the preparation of pharma IJRPC 2017, 7( 3 ), 2 3 2 - 2 3 8 et al. ISSN: 2231  2781 232 INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com TO STUDY AND UNDERSTAND THE PROCESS OF Xiaomei. Zhang. IHEP Computing . Center. Outline. Overview of IHEP experiments. General Challenges . Challenges and practice of software. JUNO Neutrino experiment . Status and challenges of computing. wet granulation method . Presented by . Assistant Lecturer: Aula Jawad. Steps of Wet Granulation. weighing and mixing of the ingredients. Specified amounts of active ingredients, fillers, and disintegrating agents are mixed until a homogeneous mixture is formed. Quantitative Engineering Approaches. What do we know?. How do we design experiments and scale ?. Implications. Nothing except parameters we can vary. Statistical Experimental Design . Lots of experiments at all scales.