Rhabdomyosarcoma OBJECTIVES To evaluate relapse patterns in rhabdomyosarcoma RMS patients after radiotherapy RT Serra Kamer ¹ Meltem Öztürk ¹ Eda Ataseven ID: 931977
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Relapse Patterns and Related Prognostic Factors After Radiotherapy in Childhood
Rhabdomyosarcoma
OBJECTIVES:
To
evaluate relapse patterns in rhabdomyosarcoma (RMS) patients after radiotherapy (RT).
Serra Kamer¹, Meltem Öztürk¹, Eda Ataseven², Bengü Kadığolu³, Haldun Öniz⁴, Mehmet Kantar², Yavuz Anacak¹¹Ege University Faculty of Medicine Department of Radiation Oncology²Ege University Faculty of Medicine Department of Pediatric Oncology³Behcet Uz Children’s Hospital Department of Pediatric Oncology⁴Tepecik State Hospital Department of Pediatric Oncology
MATERIALS AND METHODS:
Serra Kamer, MD
Ege
University Faculty of Medicine, Department of Radiation Oncology serra.kamer@ege.edu.tr
72 patientsMedian age: 5(1-18)F/M: 0.67
01/
2001 - 12/2018
Tumor localization:
Head and neck: n=31 (43%)Bladder: n=12 (16,7%)Genitourinary system: n=8 (11,1%)Extremities: n=6 (8.3%)
Surgery
: 50 patients (69.4%) Chemo.: 72 patients (100%)Concomitant CRT: 22 patients (30.6%) External RT: 51 patients (70.8%)Brachytherapy: 21 patients (29.2%)
RESULTS
: Most frequent histopathological subtype was embryonal in 45 (62,5%)Recurrence developed after radiotherapy in 19 patients (26.4%) (7 local and 2 lymphatic).Median time to recurrence was 31 months (range: 1-208). Median follow-up was 64 months (range: 2-208). 5-year overall and disease-free survival were 69.4% and 52.9% respectively.Table 1: According to IRS V staging p<0.001 In multivariate analysis, initial metastatic disease is related with lower survival (40.9 vs 80.6%, p<0.001). Long term side effects were recorded in 7 patients (growth delay in 4, permanent alopecia in 2), one patient with NF1 developed secondary tumor.
CONCLUSION
S: Radiotherapy is important part of the treatment in childhood RMS. Our results are similar to the other reports. Multidisciplinary approach is key to the successful management of RMS.
IRS V STAGELOWMEDIATEHIGH5 YS87,5 %76,9 %30,7 %