PPT-Cholesterol metabolism Anil Gattani

Functions of Cholesterol a precursor of steroid hormones progesterone testosterone estradiol cortisol etc a precursor of bile acids a precursor of vitamin D important component of many mammalian . Digestion and Absorption of Dietary Lipids.  . Lipids are taken in the diet . mainly as . triacylglycerol. . In addition, small amounts of phospholipids, cholesterol, . carotenoids. and fat-soluble vitamins are taken in diet.. Dr. Nikhat Siddiqi. 1. Overview. Cholesterol, the characteristic steroid alcohol of animal tissues, performs a number of essential functions in the body. . C. holesterol is a structural component of all cell membranes, modulating their fluidity, and, in specialized tissues, cholesterol is a precursor of bile acids, steroid hormones, and vitamin D. . Chapter 29, . Stryer. Short Course. Lipid anabolism. Triacylglyderides. Membrane components. Cholesterol. Regulation. Steroids. TAG Synthesis. Mainly in Liver. Packaged in chylomicrons. Cholesterol Biosynthesis. UNIT III:. Lipid Metabolism. HDL . comprise a heterogeneous family of lipoproteins with a complex metabolism that is not yet completely understood. . HDL particles are formed in blood by the addition of lipid to . Fat and Glycerophospholipid Synthesis. 1. 2. 3. 1. 2. 3. 1. 2. 3. Phosphatidic . Acid. Glycerol-3-P. Fat (Triacylglycerol). Glycerophospholipids. Fat Breakdown. Signaling. Catalysis. Glycero. Phospho. Cholesterol is an essential lipid constituent of cell membranes. Cholesterol is a precursor of steroid hormones and of bile acids. Intermediates of cholesterol biosynthesis are required to make vitamin D and for posttranslational modification of membrane proteins. Plasma lipoproteins. Prof. Mamoun Ahram. Resources. This lecture. Lippincott’s Biochemistry, Ch. 18. Characteristics of lipoproteins. Lipoproteins function to . Solubilize and carry plasma lipids. Transport lipids to (and from) the tissues. Ray . Hreiche. (updated slides from . Mohana. . Ratnapalan. & Anna . Sher. ). (THANK YOU!!!). Learning Objectives . Explain the physiological functions of cholesterol in membrane stability.. Outline the synthesis of cholesterol from acetate.. UNIT-I. Anil Gattani, Ajeet Kumar. Molecules Related to Cell Permeability. Depends on . Molecules size (electrolytes more permeable). Polarity (hydrophillic). Charge (anion . vs. . cation). Water . vs. What are lipids?. If so, how are these water insoluble molecules transported from one tissue to other through an aqueous environment?. Mark the hydrophobic and hydrophilic parts on these molecules. FA. Dr. . Haidar. F. Al-. Rubaye. . Lipids are an essential nutrient with diverse functions. Lipids, also known as fats and oils, are:. One of the 6 main groups of nutrients absorbed from the diet. A major source of energy that can be stored over long periods (body fat). Oxidative Deamination. Oxidative deamination. Removes the amino group as an ammonium ion from glutamate.. Provides . -ketoglutarate for transamination.. Mainly in liver and kidney. Oxidative Deamination . UNIT-I. Anil Gattani, Ajeet Kumar. Biochemistry. 2. Biochemistry has become the foundation for understanding all biological . processes. . It has provided explanations for the causes of many diseases in humans, . Cholesterol. Prof. Mamoun Ahram. Resources. This lecture. Lippincott’s Biochemistry, Ch. 17. Cholesterol in the body. The balance between cholesterol influx and efflux is not precise, resulting in a gradual deposition of cholesterol in the tissues, particularly in the endothelial linings of blood vessels..