Prolotherapy a regenerative injection therapy has been reported to be effective in rigorous randomized controlled trials The standard injection protocol includes injections inside and around the knee ID: 931797
Download Presentation The PPT/PDF document "The Research Question Knee osteoarthriti..." is the property of its rightful owner. Permission is granted to download and print the materials on this web site for personal, non-commercial use only, and to display it on your personal computer provided you do not modify the materials and that you retain all copyright notices contained in the materials. By downloading content from our website, you accept the terms of this agreement.
Slide1
The Research Question
Knee osteoarthritis (OA) is common, debilitating and often refractory to routine care.
Prolotherapy
, a “regenerative”
injection therapy
, has been reported to be effective in rigorous randomized controlled trials.
The standard injection protocol includes injections inside and around the knee
joint, but requires special training, limiting access.
Study
question:
Among
adults with knee OA, what is the effect of a brief prolotherapy injection protocol, compared to blinded saline injections, on knee pain as assessed by a validated questionnaire?
Slide2Research Design and Method
Design: 12-month blinded randomized controlled trial (N=76)
Participants: Adults with knee OA.
Intervention: Participants were allocated
to 4 monthly
ntra
-articular injections of prolotherapy (hypertonic dextrose) or control (saline).
Assessment: Western
Ontario McMaster University Osteoarthritis Index (WOMAC) pain
sub-scale (0-100 points).
Slide3What the Research Found
76 participants
High adherence
to treatment and
questionnaires
completion.
Dextrose
prolotherapy participants reported
over
22 points of change on the
WOMAC
pain
scale;
control participants reported about 10 points;
D
ifference
between groups was
statistically
and clinically significant at
6
and 12
months.
Satisfaction
with dextrose prolotherapy was
high
No
adverse events were reported.
Slide4What this means for Clinical Practice
P
rolotherapy
using 25% dextrose as the injectant safely reduced pain by clinically relevant margins through 12 months.
The
procedure, a single intra-articular injection delivered monthly for 4 sessions, is straightforward and routinely taught
as part of
conventional medical training.
These
findings suggest that dextrose prolotherapy may be a safe, accessible therapy ready for routine care of knee OA.