Xu Xiaoting Zhang Junyi C hang WeiSun QingYang YiQiu HaiboLiu Ling Department of Critical Care Medicine Zhongda Hospital Southeast University Background and Aim M echanical ventilation may cause ID: 931845
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Slide1
Correlation between muscle specific microRNA in plasma and diaphragmatic dysfunction in patients undergoing mechanical ventilation
Xu Xiaoting, Zhang Junyi，Chang Wei，Sun Qing，Yang Yi，Qiu Haibo,Liu LingDepartment of Critical Care Medicine, Zhongda Hospital, Southeast University
Slide2Background and Aim
Mechanical ventilation may cause ventilator-induced diaphragmatic dysfunction (VIDD)Mechanical ventilation induced diaphragmatic wasting atrophy is the most important mechanism of VIDD
miRNA is widely participated in regulation
of m
uscular atrophyTo investigate the relationship between plasma miRNA and diaphragmatic function in mechanical ventilation patients
Slide3Method
Screening of muscle specific miRNASingle-center prospective study
Undergoing
scheduled
cardiac surgery whose total time
of
controlled
MV is greater than 12h and less than 48 hExclusion criteria: Severe respiratory central depression, can not placed EAdi catheter, pregnancy
Included patients
the third days after operation
before extubation
one
day before operation
Detection of plasma MyomiR leve
l
Measurement of
s
keletal
m
uscle
t
hickness by Ultrasound
Measurement of
d
iaphragmatic function by Ultrasound
Slide4Result
Patient characteristics
n = 40
Age, years
59.1±12.3
APACHE Ⅱ score
13.9±5.2
SOFA score
9.3±3.0
Total mechanical ventilation time (h)
26.1±2.3
Controlled mechanical ventilation time (h)
22.1±2.2
VT / IBW(ml/Kg)
6.1±1.6
PEEP（cmH
2
O）
5.6±1.3
FiO2(%)
42.5±4.9
Assisted mechanical ventilation time (h)
2.9±1.7
ICU hospital stay（d）
2.5±2.4
Type of operation CABG n(%)
20(50.0%)
Cardiac valve replacement n(%)
17(42.5%)
Operation duration (h)
5.1±1.4
miR-1
miR-133amiR-27amiR-29bmiR-181amiR-206miR-486
→
no significant change in the thickness
of
s
keletal
m
uscle
→
level of plasma miR-1 and miR-206 was significantly low before extubation
Slide5Result- short time mechanical ventilation lead to decrease of diaphragmatic function
decrease of plasma miR-206 level positively correlated with the decrease of diaphragm function
Note: compared with 1 days before operation, * P<0.05; compared with before extubation,
#
P<0.05
Slide6Conclusion
The decrease of plasma miR-206 level is positively correlated with the decrease of
diaphragm function
in mechanically ventilated patients
Thank you