PPT-Chiral sulfoxides as ligand in asymmetric catalysis

by Nicolas Gaeng LSPN Group seminar Lausanne September 29 th 2016 Outline Introduction Structure and bonding of chiral sulfoxides History pioneer work Preparation of chiral . C344. Overview. Asymmetric catalysis. Lab overview. Organometallic reactions. Chiral GC analysis. Optical Activity. Asymmetric Catalysis. Asymmetric Synthesis. Stereoselectivity. . Diastereomeric. excess. Atkins’ Physical Chemistry. 9e. Chapter 23: . Catalysis. Chapter 23: Catalysis. . . catalyst, . a substance that accelerates a reaction but undergoes no net chemical change.. . . enzyme, . Rate of reactions. Rates of Reactions. The rate of reaction is . the . change. . in concentration. per unit time. of any one reactant or product.. Exam Q (Hons). 2003 Q7. 2004 Q8. 2007/Q9. 2011 /Q5. dynamics in. . hard. . processes. M.V.Polyakov. http://www.tp2.rub.de/~maximp. Ruhr-University Bochum. Chiral symmetry breaking - the phenomenon shaping our World . New . soft pion . theorems in hard processes– how ChSB works for colour clusters. usna. . si110. Symmetric Encryption Limitations. Symmetric encryption algorithms use the . same key for encryption and decryption. Both parties must agree to a secret key. Fundamental limitation. How do you exchange a secret key?. Transferases and hydrolases catalyze group transfer reactions. Acyl transfer:. Hexo. kinase. catalyzes a phosphoryl transfer from ATP to glucose. Glycosidases. are hydrolases, catalyzing hydrolysis of . Field Theory: . σ. Bonding. a. 1g. t. 1u. e. g. Combination of Metal and Ligand Orbitals in an Octahedral Complex. 2. Overlap of metal . orbitals. and linear combination of . ligand. group . orbitals. Pratt & . Cornely. . Ch. 6. Enzymes. Biocatalyst—active site. Proteins. Substrate. Reaction specificity. Stereospecificity. Coupled reactions. Regulation. Rate Enhancement. Orotidine. Decarboxylase. Pratt & . Cornely. . Ch. 6. Enzymes. Biocatalyst. Active site. Substrate/Product. Reaction specificity. Stereospecificity. Coupled reactions. Regulation. Rate Enhancement. Orotidine. Decarboxylase. H imines s. Wangqing Kong . Zhu’s group meeting. 2. 3. th. , Feb, 2017. Outline. 1. I. ntroduction. 2. . Methods for C. ontrol of . Asymmetr. y . in Radical Chemistry. . (1) . Chiral Lewis Acid Chelation. CATALYSIS APPLICATIONS Catalysis Applications Catalysis is the process of increasing the rate of a chemical reaction by the addition of a substance known as a catalyst. The reaction itself does not c . 6.2: Nomenclature . of . s. tereocenters. 6.3: . Properties of . asymmetric . molecules. 6.4: . Optical . isomerism. 6.5: . Fisher . p. rojections. 6.6: . Molecules with . two . s. tereocenters. 6.7: . 1. T.A. Cochran, I. Belopolski, K. Manna, M. Yahyavi, Y. Liu, D.S. Sanchez, . Z.-J. Cheng, X.P. Yang, D. Multer, J.-X. Yin, H. Borrmann, A.Chikina, J.A. Krieger, J. Sánchez-Barriga, P. Le Fèvre, F. Bertran, V.N. Strocov, J.D. Denlinger, T.-R. Chang, S. Jia, C. Felser, H. Lin, G. Chang, and M.Z. Hasan, .