PPT-Descending Inhibition of Pain

Roland Staud MD Professor of Medicine University of Florida Outline Endogenous Pain Modulation is Variable in Healthy Individuals and Patients Genetic and Environmental Factors Endogenous Pain Inhibitory Function Is Inefficient in Many Chronic Pain Disorders. 1 Competitive Inhibition Fig 8- 2 Competitive InhibitionCTEuli S + S E P + E c = K . ( [ c / K c / Vx sl re S bu i n a S bd t fee E a a s wre S bd c w S f fee E S IMMPACT. -. XVI meeting. Washington, DC. Simon Haroutiunian. B.Sc.Pharm. , . M.Sc. (Clinical Pharmacy), PhD. Danish Pain Research Center. Aarhus University Hospital. Aarhus, Denmark. Conditioned Pain Modulation (CPM). Inhibition is a term used to describe the inability of a product being formed due to the presence of another substance (the inhibitor). Enzyme inhibition . can be competitive or noncompetitive. Competitive inhibition is caused when an inhibitor “competes” with the substrate in binding with the enzyme. Pratt & . Cornely. . Ch. 7. Other Factors. Other factors affect enzyme activity. Temperature. pH . pH Optimum. Determined by structural stability. Compartmentalization. Determined by active site residues. BY DR KAUKAB AZIM. 1. Learning Outcomes. By the end of the lecture the student should be able to . Define and discuss the pathobiology of pain pathways. Explain . the molecular mechanism of action common to all .  Distribute to contractors  Post on HSE Notice Boards  Include in site HSE Induction. PDO Safety Advice. Date:. . 25. th. . May . 2014. Injury: Elbow fracture. What . happened. ?. While descending the last 2 steps to the ground floor. By: . Jingtian. . Weng. , Cindy Nguyen, Cassandra Lee, Sarah Bento-De Sousa. Presentation Date: Sept. 13, 2016. PHM142 Fall . 2016. Instructor: Dr. Jeffrey Henderson. What is COX?. Two homodimer enzymes COX-1 and COX-2. Pratt & . Cornely. . Ch. 7. Enzyme Kinetics. How fast an enzyme catalyzed reaction goes. Why study enzyme kinetics?. Helps us understand mechanism of enzyme (how it works). Investigation of mutations in metabolic pathways. The structure of a noncompetitive inhibitor does not resemble the substrate and does not compete for the active site. .. Learning Goal . . Describe competitive and . noncompetitive inhibition . and reversible and irreversible inhibition. Definisi nyeri :. International . Association for . the Study . of Pain (IASP) . : . “. Nyeri adalah pengalaman sensorik dan . emosional . yang . tidak menyenangkan akibat kerusakan jaringan, baik aktual maupun potensial . Inhibition-. The decrease in enzyme activity/loss of activity. exert effect by decreasing . affinity of the enzyme for the substrate. decreasing the amount of active enzyme available for catalysis. by a combination of these effects. Definition. Generally TENS is applied at high frequency (>50 Hz) with an intensity below motor contraction (sensory intensity) or low frequency (<10 Hz) with an intensity that produces motor contraction.. AMVAC Chemical Corporation. FMC Corporation. Gowan. Company. September 15-18, 2020. Outline of Presentation. Introduction to Testing Program (Rick Reiss) – 15 minutes. Experimental Procedures and Results (Jan Chambers) – 20 minutes. Pathways descending from the brainstem are important in regulating and modulating pain. 1,2. Descending pathway neurons use . noradrenaline and serotonin. 2,3. Neurons in the descending pathway may control pain via:.