Circulation 2014129587597 Teaching Tool Hyperfiltration Early Sign of Hypertension and Diabetes J Am Soc Nephrol 20172810231039 Hyperfiltration Early in Diabetic Nephropathy Circulation 2016134752772 ID: 774971
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Slide1
Diabetes and Hypertension Accelerate Glomerular Hypertension
Circulation 2014;129:587-597
Slide2Teaching Tool: Hyperfiltration Early Sign of Hypertension and Diabetes
J Am Soc Nephrol 2017;28:1023-1039
Slide3Hyperfiltration Early in Diabetic Nephropathy
Circulation 2016;134:752-772
Slide4SGLT2 Inhibition Reduces Hyperfiltration
Circulation 2016;134:752–772
Slide5SGLT2 Inhibition + RAAS Blockade =Afferent Constriction + Efferent Dilation
Diabetologia 2014;57:2599-2602
GLP-1 agonist also modestly ↓ hyperfiltration
Slide6Lancet Diabetes Endocrinol 2015;3:514-525
eGFR (<60 >105) and UACR > 5 Associated ↑ CV Mortality, ↑CHD, Stroke, and Heart Failure
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HR: 1.0eGFR95 mL/min/1.73 m2
HR: 1.0UACR 5 mg/gcreatinine
eGFR
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Hyperfiltration
UACR
Slide7Insulin Resistance Promotes Glomerular Hyperfiltration
Sci Rep 2017;7:45522, 10.1038/srep45522
Slide8Insulin Resistance Promotes Kidney Dysfunction
Nephrol Dial Transplant 2013;28:29–36