PPT-Neonatal Cholestasis for Neonatologists

Jay Hochman mD GI Care For Kids August 3 2017 Learning Objectives Understand the causes of neonatal cholestasis Learn about advances in diagnosis of neonatal cholestasis and appropriate use of genetic panels. Document title: Neonatal resuscitation Publication date: October 2011 Document number: MN11.5-V2-R16 Document supplement The document supplement is integral to and should be read in conjunction with Green-top Guideline No. 43. April 2011. Prof. of Ob, Gyn . Al Azhar University (Domiate). Prof. . Mahmoud. . Midan. . Definition. Obstetric cholestasis is a multifactorial condition of pregnancy characterised by . James . Nuttall. Paediatric. Infectious Diseases Unit, . Red Cross War Memorial Children’s Hospital & University of Cape Town. Right to Care 6. th. Conference on Emerging Problems in . Paediatric. Erin L. Keels RN MS NNP-BC. NAS Taskforce Chair. NNP Program . Manager. Nationwide Children’s Hospital . Columbus, Ohio . Disclosures. No conflicts of interest. Off label use of medications for treatment of NAS. Ferris State University. Kelly . Geraghty. , Tracy James, Kristen . Lintjer. , . Sara . Potes. , . Rikki. . Zissler. PICO Question. “Are newborn infants with high neonatal abstinence syndrome scores (8 or above) more responsive when nurses treat them with pharmaceutical or non-pharmaceutical interventions?” . Case 3.13. 1. Chapter 3. Fatty Liver Diseases. Clinical Presentation. A 46-year-old woman with a history of chronic alcohol intake and hypothyroidism presented with symptoms of alcohol withdrawal.. Physical exam revealed jaundice, palmar erythema, spider angioma, and telangiectasia formation over her face. . Liver and gastrointestinal disease. Physiological changes in pregnancy. Relaxation of smooth muscle resulting in:. decreased lower oesophageal sphincter pressure. decreased gastric peristalsis. delayed gastric emptying. Overview. Definition. Production & metabolism. Measurement of . bilirubin. – serum & urine. Approach to the patient. Broad Differential Diagnosis. Work-up for “Medical” Jaundice. Work-up if Obstructive Jaundice. Cholestasis . is defined as reduced bile flow and is characterized by . elevation of . the conjugated, or direct, bilirubin fraction. . This . condition must . be distinguished . from physiological neonatal jaundice, in which the . . Elniema. Objectives. • . Definition of jaundice . • . Metabolism of . bilirubin. . • . Types of jaundice . • . Causes of neonatal jaundices . • . Management of neonatal jaundice. Definition . I. ntrahepatic . C. holestasis. (PFIC 1~3). Definition. A heterogeneous group of disorders. in which . cholestasis of hepatocellular origin. often presents in the neonatal period or first year of life . 62 different problems related to the fact that the protec-tive effect of the gut is breached. These are first theteria. The liver, as the target organ of these aspects ofPN-INDUCED CHOLESTASIS DEFINED 1 Intrahepatic cholestasis of pregnancy Description Intrahepatic cholestasis of pregnancy is a liver disorder that occurs in pregnant women. Cholestasis is a condition that impairs the release of a d Rawashdeh. , MD, . MSc. , FRCP, FRCPCH. Professor of Pediatrics . & . Gastroenterology. Jaundice: Definition. Yellow staining of the skin and sclera by abnormally high blood levels of the bile pigment .