and other macrocytic anaemias Introduction to macrocytic anaemia In macrocytic anaemia the red cells are abnormally large mean corpuscular volume MCV gt98 fL There ID: 918602
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Slide1
Megaloblastic anaemiasand other macrocyticanaemias
Slide2Introduction to macrocytic anaemia
In
macrocytic
anaemia
the red cells are abnormally large (
mean corpuscular
volume, MCV >98
fL
).
There
are several
causes but
they can be broadly subdivided into
megaloblastic
and non‐
megaloblastic
based on the
appearance of developing erythroblasts in the bone marrow.
Slide3Slide4Megaloblastic anaemias
This is a group of
anaemias
in which the erythroblasts
in
the bone
marrow show a characteristic abnormality – maturation
of the nucleus being delayed relative to that of the cytoplasm.
The underlying defect accounting for the asynchronous maturation
of the nucleus is defective DNA synthesis and this is
usually caused by deficiency of vitamin B12 or
folate
.
Less commonly,
abnormalities of metabolism of these vitamins or other
lesions in DNA synthesis may cause an identical
haematological
appearance
Slide5Slide6Slide7Slide8Slide9Slide10Slide11Slide12Slide13Slide14Slide15Slide16Slide17Slide18Slide19Slide20Slide21Slide22Slide23Slide24Slide25Slide26Slide27Other megaloblastic anemia
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