PPT-Gene Therapy 6.3 – Manipulating genomes

Starter Comparing DNA processes Process What does it do How does it work PCR Polymerase Chain Reaction DNA Sequencing DNA Profiling Gel Electrophoresis Process What does it do How does it work. INTRODUCTION. Most developments in biotechnology originated for their potential applications in health care.. Contribution of biotechnology:. Diagnosis of diseases. Therapeutic agents. Correction of genetic disease-Gene therapy. Organelle gene expression processes. Organelle-to-nucleus signaling. (retrograde regulation). PCB6528 Plant Cell and Developmental Biology Spring . 2012. Organelle genomes, gene expression and signaling. Production Genomics Facility. “. User facility. providing high-throughput DNA sequencing & analysis in support of DOE missions in alternative . energy. , . carbon cycling . & . bioremediation. Comparative genomics of sponges, sea anemones, and multicellular pancakes. Mansi Srivastava. Rokhsar Lab, Department of Molecular and Cell Biology, UC Berkeley. Reddien Lab, Whitehead Institute for Biomedical Research. Aljazy. . AlShehween. Informative speech. Outline . Introduction . What is massage therapy?. What are the types?. What are the benefits?. What are the risks?. Conclusion . Definition . Massage is the manipulating of superficial and deeper layers of muscle and connective tissue using various . to correct a . genetic defect . by transferring of a . functional normal copy. of the gene into cells. Examples of diseases caused by genetic defect. Ornithine . transcarbamylase. (OTC deficiency). By Kole Drumheller and Austin Dillard. Gene Therapy. What is Gene therapy?. This is a technique that is designed to introduce new genetic material into cells to help fix abnormal genes or to make a new protein that will help the person.. 6.1 Introduction to Genomics. 6.2 Sequencing Genomes. 6.3 Bioinformatics and Annotating Genomes. 6.1 Introduction to Genomics. Genome. Entire complement of genetic information. Includes genes, regulatory sequences, and noncoding DNA. Kyle Orwig. Magee-. Womens. Research Institute. University of Pittsburgh School of Medicine. International Summit on Human Gene Editing:. A Global Discussion. December 1-3, 2015. Stem Cell. Renewal. Therapy of enzyme defects: general considerations. How many organs are affected by the enzyme defect: One organ, a few, or all organs?. How severe is the defect?. Can the defect be adequately controlled by conventional treatment?. Circularly Permuted Genomes. Some phages have circularly permuted genomes. This means a linear concatamer of phage DNA is synthesized, used to fill a phage head, then cut when the head is full. Generally, one head will fit more than 100% of a genome, say, 103-110%. This ensures that wherever the DNA is cut, at least one working copy of each gene is present.. Gene therapy . is when DNA is introduced into a patient to treat a genetic disease. The new DNA usually contains a functioning gene to correct the effects of a disease-causing mutation. . Gene therapy uses sections of DNA (usually genes) to treat or prevent disease. The DNA is carefully selected to correct the effect of a mutated gene that is causing disease. The technique was first developed in 1972 but has, so far, had limited success in treating human diseases. Gene therapy may be a promising treatment option for some genetic diseases, including . Campadelli-Fiume G, Mirandola P, Menotti L. Human Herpesvirus 6: An Emerging Pathogen. Emerg Infect Dis. 1999;5(3):353-366. https://doi.org/10.3201/eid0503.990306. Cell therapy is defined as the administration of live whole cells or maturation of a specific cell population in a patient for the treatment of a disease. . – Bone Marrow Transplantation. Bone . Marrow Transplantation for DBA.