PPT-Gene Therapy 6.3 – Manipulating genomes

Starter Comparing DNA processes Process What does it do How does it work PCR Polymerase Chain Reaction DNA Sequencing DNA Profiling Gel Electrophoresis Process What does it do How does it work. & . Genome evolution. Genomes and Genome Evolution - BIOL 4301/6301. What to expect and some suggestions.. I . like think . of . myself as . fair but reasonably tough. I want people to do well but I’m not willing to compromise on the material or ethical guidelines to make it happen.. Chromosome. —. A . string like. , gene-containing molecule in the nucleus of a . cell. Gene. —. The fundamental unit of biological . inheritance. Genome. —An organism’s entire complement of DNA. Chapter 21. You must know. How prokaryotic genomes compare to eukaryotic genomes.. Applications of bioinformatics to medicine, evolution, and health.. The activity and role of transposable elements and retrotransposons in generating genetic diversity.. William Brooks. Medicinal Chemistry. March 31, 2011. Outline. Conventional drug design vs. gene therapy. Examples of genetic engineering. Types of gene therapy. Mechanisms. Delivery vectors. Viral. Non-viral. By Kole Drumheller and Austin Dillard. Gene Therapy. What is Gene therapy?. This is a technique that is designed to introduce new genetic material into cells to help fix abnormal genes or to make a new protein that will help the person.. 6.1 Introduction to Genomics. 6.2 Sequencing Genomes. 6.3 Bioinformatics and Annotating Genomes. 6.1 Introduction to Genomics. Genome. Entire complement of genetic information. Includes genes, regulatory sequences, and noncoding DNA. What you need to know:. The major goals of the Human Genome Project.. How . prokaryotic genomes compare to eukaryotic genomes. .. Applications of bioinformatics to medicine, evolution, and health.. The activity and role of transposable elements and . 15.1 Personal DNA Testing. About 99% of your DNA is the same as everyone else. ’. s. A nucleotide difference found in at least 1% of a population is called a . single-nucleotide polymorphism (SNP. ) . Genetic Counseling. Treating . Genetic . Disease. Removing . an affected body . part.. Replacing . an affected body part or biochemical . with material . from a . donor.. Delivering . pure, human proteins derived . 6000. inherited human diseases catalogued to date, only a few are currently treatable.. Gene therapy. —introducing functional copies of a gene into an individual with two defective copies of the gene—is a potential tool for treating inherited human diseases.. Gene therapy . is when DNA is introduced into a patient to treat a genetic disease. The new DNA usually contains a functioning gene to correct the effects of a disease-causing mutation. . Gene therapy uses sections of DNA (usually genes) to treat or prevent disease. The DNA is carefully selected to correct the effect of a mutated gene that is causing disease. The technique was first developed in 1972 but has, so far, had limited success in treating human diseases. Gene therapy may be a promising treatment option for some genetic diseases, including . Cell therapy is defined as the administration of live whole cells or maturation of a specific cell population in a patient for the treatment of a disease. . – Bone Marrow Transplantation. Bone . Marrow Transplantation for DBA. Peter Marks, MD, PhD. National Press Foundation. November 17, 2023. Outline. Status of gene therapy and genome editing. Regulatory considerations for genome editing. Regulatory guidance for genome editing. Specification Reference. Learning Objective. Understand the principles of genetic engineering. . Understand the techniques used in genetic engineering.. Success Criteria. Describes the steps involved in isolating and then transferring a gene into a vector..