PPT-Genome Evolution Xuhua Xia

xxiauottawaca httpdambebiouottawaca Definitions Genome the entire complement of genetic material carried by an individual Transcriptome with two definitions the entire set of transcribable sequences from the genome operationally all RNA sequences from annotated productive genes in a genome. Fitting Several Regression Lines. Many applications of statistical analysis involves a continuous variable as dependent variable (DV) but both continuous and categorical variables as independent variables (IV). . Active Roles in Evolution of . Immunity and Pregnancy . Retroviruses 2015. Chicago, June 8, 2015. James A. Shapiro. University of . Chicago. jsha@uchicago.edu. www.shapiro.bsd.uchicago.edu. . Evolutionary time: Genome writing . Chapter 21. You must know. How prokaryotic genomes compare to eukaryotic genomes.. Applications of bioinformatics to medicine, evolution, and health.. The activity and role of transposable elements and retrotransposons in generating genetic diversity.. Xuhua Xia. xxia@uottawa.ca. http://dambe.bio.uottawa.ca. Xuhua Xia. Slide . 2. Lecture Outline. Objectives in this lecture. Grasp the basic concepts distance-based tree-building algorithms. Learn the least-squares criterion and the minimum evolution criterion and how to use them to construct a tree. Many applications of statistical analysis involves a continuous variable as dependent variable (DV) but both continuous and categorical variables as independent variables (IV). . Relationship between DV and continuous IVs is linear and the slope remains the same in different groups: ANCOVA.. Key considerations:. Genes . Chromosomes. C value paradox. Gene regulation. Epigenetics. Transposable elements. DNA . ……..……..mRNA……….…….Protein . Plant . Estimated # genes. Arabidposis. Key considerations:. Genes . Chromosomes. C value paradox. Gene regulation. Epigenetics. Transposable elements. DNA . ……..……..mRNA……….…….Protein . Plant . Estimated # genes. Arabidposis. Jan Pačes. Institute of Molecular Genetics AS CR. sizes of selected completed genomes. genome. chromosomes. size. genes. Mycoplasma. . genitalium. 0.58 . Mbp. 521. Escherichia coli. 4.6 . Mbp. (5.4. What you need to know:. The major goals of the Human Genome Project.. How . prokaryotic genomes compare to eukaryotic genomes. .. Applications of bioinformatics to medicine, evolution, and health.. The activity and role of transposable elements and . Summary of Research Interests. Gene identification and genome annotation. The evolution of genome-sequence compositional properties. Models of protein evolution. The phylogeny of Bacteria. Measures of differentiation from genomic and . Xuhua Xia. xxia@uottawa.ca. http://dambe.bio.uottawa.ca. Xuhua Xia. Slide . 2. Normal and Thalassemia HBb. Are the two genes homologous?. What evolutionary change can you infer from the alignment? . What is the consequence of the evolutionary change?. Xuhua Xia. xxia@uottawa.ca. http://dambe.bio.uottawa.ca. Xuhua Xia. Slide . 2. Normal and Thalassemia HBb. Are the two genes homologous?. What evolutionary change can you infer from the alignment? . What is the consequence of the evolutionary change?. [22]. The pattern of blocks was assessed to see whether theirarrangement in the ancestral genome prior to duplicationarrangement in the ancestral genome prior to duplicationequally parsimonious series PCA: principal component analysis. Correspondence analysis. Canonical correlation. Discriminant function analysis. Cluster analysis. MANOVA. PCA. Given a set of variables . x. 1. , . x. 2. , …, . x.