PPT-Colocalization of synapsin I and Munc13 within presynaptic

Michael P Tekin and William L Coleman Department of Biological and Allied Health Sciences Bloomsburg University 400 E 2 nd St Bloomsburg PA 17815 Abstract Synapsins are a group of proteins classically thought to regulate synaptic vesicle cycling well upstream of vesicle exocytosis Several previous studies however have suggested that synapsin I may have multiple regulatory roles including functions closer in time to the actual release event This led to the hypothesis that synapsin I may interact with the major vesicle priming protein Munc13 Synapsin I Munc13 interaction was investigated using double immunofluorescence staining at earthworm . What . you are expected to gain from this lecture:. 1. . Approaches. 2. . . In-vivo . vs. . in-vitro . preparations. 3. . Advantages & Pitfalls. 4. . Types of Measures. 5 Common . Ephys. Approaches:. Neurons: Cellular and Network Properties. Figure 8-20. Cell-to-Cell: A Chemical Synapse. Chemical synapses use . neurotransmitters; electrical synapses pass electrical signals.. Axon of. presynaptic. presynaptic ending – . portion of the . axon . conveying information to the next neuron. . Some terms…….. presynaptic ending – . the portion of the axon that is conveying information to the next neuron. Neurons: Cellular and Network Properties. Integration: Divergence. Figure 8-25a. Integration: Convergence. Figure 8-25b. Integration: The Abundance of Synapses on a Postsynaptic Neuron. Figure 8-26. Axon terminals. นพ. . สโรจน์. . ศิ. ริ. มะณี. วัฒนา. ภาควิชาวิสัญญีวิทยา. ศูนย์การแพทย์ปัญญา. นันท. Presynaptic events maybe generated by certain transmitter(s).. Somorjai Dávid. N. eurotransmitters. Neurotransmitters are endogenous bioactive substances . Substances used as neurotransmitters belong to three. distinct families:. Endocannabinoid Signaling Pathways. Gaurav . Anand, Christa Montgomery, . Ahsan. . Hussain. , Heather . Johnson, Peter . Koulen. Vision Research Center, Department of Ophthalmology, School of Medicine, University of Missouri-Kansas City, MO. Lecture . 5. Dr. Amar AL-. M. usawi. MD, PhD. Synaptic plasticity:. . It is the changes in the synaptic functions as a result of the history of discharging at a synapse, i.e. synaptic conduction can be strengthened or weakened on the basic of past experience. . chemical. or . electrical. signal transmission between neurons. . In a chemical synapse, the . axon terminal . of the presynaptic neuron packages . neurotransmitters. into synaptic vesicles.. Calcium ions trigger the fusion of synaptic vesicles to the presynaptic membrane, releasing its cargo into the . Nuha. . Alkhawajah. MD. Disorders affecting the junction between the presynaptic nerve terminal and the postsynaptic muscle membrane. Pure . motor syndromes . Preferentially . affect proximal, bulbar, or . Martines RB, Ritter JM, Matkovic E, Gary J, Bollweg BC, Bullock H, et al. Pathology and Pathogenesis of SARS-CoV-2 Associated with Fatal Coronavirus Disease, United States. Emerg Infect Dis. 2020;26(9):2005-2015. https://doi.org/10.3201/eid2609.202095.