PPT-Sofosbuvir + Ribavirin to Prevent Post-Transplant HCV Recurrence

Author : briana-ranney | Published Date : 2019-11-22

Sofosbuvir Ribavirin to Prevent PostTransplant HCV Recurrence Phase 2 Curry MP et al Gastroenterology 20151481007 Treatment Naïve and Treatment Experienced Liver

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Sofosbuvir + Ribavirin to Prevent Post-Transplant HCV Recurrence: Transcript

Sofosbuvir Ribavirin to Prevent PostTransplant HCV Recurrence Phase 2 Curry MP et al Gastroenterology 20151481007 Treatment Naïve and Treatment Experienced Liver Transplantation Source Curry MP et. ELECTRON (Overview): 6 parts, 22 arms. Phase . 2. Treatment. Naïve and Treatment . Experienced. Source: . Gilead Sciences, . Inc. Sofosbuvir. Summary of ELECTRON Trials Design (1 of 2). Part 1 . - . + Ribavirin to Prevent Post-Transplant HCV Recurrence . Phase 2. Curry . MP, et al. Gastroenterology. 2014;September 24. [. Epub. ahead of print] . Treatment. Naïve and Treatment . Experienced. Liver Transplantation. (. Epclusa. ). Prepared by. : H. Nina Kim, MD MSc and David . Spach. , MD. Last . Updated: . July . 8, . 2016. Background and Dosing. Sofosbuvir-Velpatasvir. (. Epclusa. ). Sofosbuvir-Velpatasvir. (. NIH SPARE. Phase . 2. Treatment. . Naïve . (unfavorable baseline treatment . characteristics). Osinusi. A, et al. JAMA. 2013;310:804-11.. Source: . Osinusi. A,. . et al. . JAMA. 2013;310:804-11.. HIV Coinfection & HCV . GT 1,2,3. PHOTON-1 Trial. Phase . 3. Sulkowski. MS, et al. JAMA. 2014;312:353-61.. Treatment. Naïve and Treatment . Experienced. HIV Coinfection. Source: . Sulkowski. MS, et al. JAMA. 2014;312:353-61.. VALENCE Trial. Phase . 3. Treatment. Naïve and Treatment . Experienced. Zeuzem. S, et al. . N . Engl. J Med. 2014;370:1993-2001. Source: . Zeuzem. S, et al. N . Engl. J Med. 2014;370:1993-. 2001.. . or 3 . LONESTAR-2. Phase 2. Treatment. . Experienced. Lawitz. . E, et al. . Hepatology. . 2015:61:769-75.. Source: . Lawitz. E, et al. . Hepatology. . . 2015:61:769-75.. Sofosbuvir + . PEG + RBV . Design. Objective. SVR. 12. (HCV RNA < 25 IU/ml) in genotype 1. DCV 60 mg . qd. + . SOF 400 mg . qd. + RBV. DCV 60 mg . qd. + . SOF 400 mg . qd. + RBV. Not . randomised. Open-label. ALLY-1 Study: DCV + SOF + RBV for advanced liver disease and post-liver transplant recurrence. -. 0938 in GT 1-4. QUANTUM. Phase . 2b. Treatment. . Naïve . Lalezari. JP, et al. EASL. 2013; Abstract 845. . Source: . Lalezari. JP, et al. EASL. 2013; Abstract 845. . Sofosbuvir, Ribavirin, & GS-0938 in . in Genotype 3. ASTRAL-3. Phase 3. . Treatment. . Naïve & Experienced. Foster GR, . et al. . N . Engl. J Med. . 2015. ;373:2608-17.. *Published in tandem with ASTRAL-2 Trial. Source: Foster GR, . SOLAR-1 (Cohorts A and B). Phase . 2 . Treatment Naïve and Treatment Experienced. Charlton M, al. Gastroenterology. 2015; 149:649-59.. Source: Charlton M, . et al. . Gastroenterology. 2015; 149:649-59.. Update. David Spach, MD. Professor of Medicine, Division of Infectious Diseases. University of Washington. Last Updated: . June 12. , 2013. Chronic Viral Diseases and Mortality in United States. Which one of the chronic viral diseases was responsible for the most number of deaths in the United States in 2007?. Following Liver Transplantation. Phase 2. Charlton M, . et al. . Gastroenterology. 2015;148:108-17.. Treatment. Naïve and Treatment . Experienced. Liver Transplantation. Source: Charlton M, et al. Gastroenterology. 2015;148:108-17.. SOLAR-2. Source: . Manns. M, et al. Lancet Infect Dis. 2016;16:685-97.. Treatment Naïve and Treatment Experienced, Phase 2. Ledipasvir-Sofosbuvir + Ribavirin in Advanced Liver Disease. SOLAR-2: Features.

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