PPT-Epilepsy Updates Newer Antiepileptic Drugs and Rescue Aid

Mikiko Takeda MS PharmD PhC Assistant Professor University of New Mexico College of Pharmacy 1 Leaning objectives Pharmacists To review pharmacology and pharmacokinetics of antiepileptic drugs AEDs and to detect possible adverse reactions at early stage. By Laura Parker. Define an epileptic seizure, epilepsy and status . epilepticus. Name common causes and factors that may predispose an individual to epileptic seizures. Recognise the symptoms a patient may present with who has epilepsy. DEPARTMENT OF GENERAL MEDICINE. MADURAI MEDICAL COLLEGE. DEFINITION. CLASSIFICATION. ETIOLOGY. MECHANISM OF SEIZURES. STAGES IN EVOLUTION GTCS. SYMPTOMS OF INDIVIDUAL SEIZURE TYPES. INVESTIGATION. MANAGEMENT. Presenter: Dr. . Shravan. Kumar. Moderator: Prof. R. K. Gaur. INTRODUCTION. Clinicians have recognized the association of epilepsy with . psychiatric disorders . since . antiquity.. . At . the turn of the 19th century, . Program Goals. Lifetime Prevalence of Psychiatric Comorbidities in Epilepsy. Mechanisms Operant in the Development of Psychiatric Iatrogenic Symptomatology. AEDs With Psychotropic Properties. Pathogenic Mechanisms for AED-Induced Depression. Definition of Epilepsy. Group of disorders characterized by. excessive excitability of neurons in the CNS. Can produce a variety of symptoms ranging from brief periods of unconsciousness to violent convulsions. Mikiko. Takeda, M.S., . Pharm.D. ., . PhC. Assistant Professor. University of New Mexico. College of Pharmacy. 1. Leaning objectives. Pharmacists. To review pharmacology and pharmacokinetics of antiepileptic drugs (AEDs) and to detect possible adverse reactions at early stage.. TARV. JHÓSEP ANDRÉS BLANCO MEJÍA. Interno Junior Farmacología Clínica. Universidad de La Sabana. CONTENIDO. Presentación de caso clínico. Consideraciones . farmacoterapéuticas. Recomendaciones. Introductions- who we are?. Amanda Pike- . Education Senior Program Manager, Epilepsy Foundation of MN. Jeannine Conway- . Pharm. D, University of MN, member of Professional Advisory Board of Epilepsy Foundation of MN. NYU Comprehensive Epilepsy Center. ANTIEPILEPTIC DRUG DEVELOPMENT. 1840. 1860. 1880. 1900. 1920. 1940. 1960. 1980. 2000. 0. 5. 10. 15. 20. Bromide. Phenobarbital. Phenytoin. Primidone. Ethosuximide. Sodium Valproate. Executive Medical Director – Neurosciences. Boys Town National Research Hospital. What is a Seizure?. A “storm in the brain”. Abnormal, synchronized electrical activity, changing a child’s movements, alertness, or sensation. Epidemiology of Epilepsy 010203040506070809001020304050607080AgeIncidence per 100,000PartialGeneralized tonic-clonicPrimary Generalized Secondarily Generalized Seizures ! Begins focally, with or with 89 Sarah Durica, . M.D.. Assistant Professor. Department of Neurology. The University of Oklahoma Health Sciences Center. EXPERIMENTAL OR OFF-LABEL . DRUG/THERAPY/DEVICE DISCLOSURE. I . will be discussing . One size does not fit all . Drug resistant epilepsy: what is it and how does it impact you and your patients?. Drug resistant epilepsy vs . Pseudoresistance. : . the importance of ruling it out. Drug resistant epilepsy .