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Addressing Cognitive and Psychiatric Effects of Antiepileptic Drugs Addressing Cognitive and Psychiatric Effects of Antiepileptic Drugs

Addressing Cognitive and Psychiatric Effects of Antiepileptic Drugs - PowerPoint Presentation

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Uploaded On 2018-10-13

Addressing Cognitive and Psychiatric Effects of Antiepileptic Drugs - PPT Presentation

Program Goals Lifetime Prevalence of Psychiatric Comorbidities in Epilepsy Mechanisms Operant in the Development of Psychiatric Iatrogenic Symptomatology AEDs With Psychotropic Properties Pathogenic Mechanisms for AEDInduced Depression ID: 688934

effects aeds psychiatric cognitive aeds effects cognitive psychiatric references iatrogenic cont adverse healthy fda generation epilepsy meta analysis volunteers

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Presentation Transcript

Slide1

Addressing Cognitive and Psychiatric Effects of Antiepileptic DrugsSlide2

Program GoalsSlide3

Lifetime Prevalence of Psychiatric Comorbidities in EpilepsySlide4

Mechanisms Operant in the Development of Psychiatric Iatrogenic SymptomatologySlide5

AEDs With Psychotropic PropertiesSlide6
Slide7

Pathogenic Mechanisms for AED-Induced DepressionSlide8

Psychiatric Adverse Effects in Patients With Epilepsy Treated With TopiramateSlide9
Slide10

Effect of Co-occurrence of Depression With

Other Histories During Rapid Topiramate Titration Slide11

Discontinuation of Levetiracetam Related to Psychiatric Adverse EffectsSlide12

Dose of Levetiracetam and Psychiatric Adverse EffectsSlide13

AEDs and Suicidality

FDA Conclusions From Meta-AnalysisSlide14

FDA Meta-AnalysisSuicidal Behavior or Ideation Stratified by AEDSlide15

FDA Meta-Analysis

Methodological ConcernsSlide16

Antiepileptic Drugs and SuicidalityExpert Consensus StatementSlide17

Risk Factors for Suicidality in EpilepsySlide18

Can Iatrogenic Psychiatric Symptoms/Effects Be Prevented?Slide19

Iatrogenic Cognitive Effects of AEDs

Basic ConceptsSlide20

Cognitive Abilities Affected by AEDsSlide21

First-Generation AEDs

Cognitive Effects in Healthy AdultsSlide22

Second-Generation AEDs

Cognitive Effects in Healthy AdultsSlide23

Newer AEDs vs Other AEDs

In Healthy VolunteersSlide24

Delayed Recall in Healthy Volunteers Slide25

Third-Generation AEDs

Iatrogenic Cognitive Effects

Slide26

AEDs With Specific Iatrogenic Cognitive Deficits Slide27

Prevention of Iatrogenic Cognitive Adverse EffectsSlide28

SummarySlide29

AbbreviationsSlide30

ReferencesSlide31

References (cont)Slide32

References (cont)Slide33

References (cont)Slide34

References (cont)Slide35

References (cont)Slide36

References (cont)