Immune Depletion, PowerPoint Presentation, PPT - DocSlides

Immune Depletion, PowerPoint Presentation, PPT - DocSlides

2017-05-05 48K 48 0 0

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Immune Modulation, and Immunosuppression in MS: . A Review . Introduction. Architecture of the Immune System: Focus on Innate Immunity. Innate Immune System Features. Architecture of the Immune System: Focus on Adaptive Immunity. ID: 544858

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Presentations text content in Immune Depletion,

Slide1

Immune Depletion, Immune Modulation, and Immunosuppression in MS: A Review

Slide2

Slide3

Introduction

Slide4

Architecture of the Immune System: Focus on Innate Immunity

Slide5

Innate Immune System Features

Slide6

Architecture of the Immune System: Focus on Adaptive Immunity

Slide7

T-Cell Development

Slide8

B-Cell Ontogeny

Slide9

B Cells: Antigen Presentation, Cytokine Release, and Antibody Secretion

Slide10

Regulatory and Proinflammatory Features of B Cells

Slide11

Effector Function of T Cells

Slide12

Immunity in the Periphery and CNS

Slide13

Adaptive Immune Response in MS

Slide14

Initiation of T-Cell Responses in MS:Scenario 1

Slide15

Initiation of T-Cell Responses in MS: Scenario 2

Slide16

Initiation of T-Cell Responses in MS: Scenario 2 (cont)

Slide17

Different Functions of Macrophages

Slide18

Potential Role of NK Cells in MS

Slide19

CNS Inflammation in MS

Slide20

Compartmentalized Inflammation in Progressive MS

Slide21

CNS Lymphatic Vessels

Slide22

Ectopic Lymphoid Follicles in Meninges

Slide23

MS: A T-Cell- or B-Cell-Driven Disease?

Slide24

A Soluble Demyelinating Factor in MS?

Slide25

Targeting the Immune System in MS

Slide26

Immunosuppressive DMTs

Slide27

Immunomodulatory DMTs

Slide28

Immune-Trafficking DMT—Blockade

Slide29

Immune-Trafficking DMT—Entrapment

Slide30

Immune-Depleting DMTs

Slide31

Overlap of DMT Classification

Slide32

Daclizumab: Enhancement of Endogenous Mechanisms of Immune Tolerance

Slide33

What Is the Most Promising Strategy for the Treatment of RRMS?

Slide34

ORATORIO Primary and Secondary Endpoints: 12- and 24-Week CDP

Slide35

INFORMS: Fingolimod in PPMS

Slide36

EXPAND Trial: Siponimod in SPMS

Slide37

Anti-CD20 Therapy in MS: MOA

Slide38

Conclusions

Slide39

Abbreviations

Slide40

Abbreviations (cont)

Slide41

Abbreviations (cont)


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