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Insulin/GLP-1 Agonist Combinations Insulin/GLP-1 Agonist Combinations

Insulin/GLP-1 Agonist Combinations - PowerPoint Presentation

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Uploaded On 2018-11-04

Insulin/GLP-1 Agonist Combinations - PPT Presentation

Program Overview Pathophysiology of Hyperglycemia Updated ADAEASD Standard of Care 2017 Delays in Intensification of Therapy The Role of Basal Insulin and GLP1 RA in Controlling Hyperglycemia ID: 714831

glp lixilan care insulin lixilan glp insulin care primary patients trials trial frcs key simultaneous basal sequential getgoal duo

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Presentation Transcript

Slide1

Insulin/GLP-1 Agonist CombinationsSlide2
Slide3

Program OverviewSlide4

Pathophysiology of HyperglycemiaSlide5

Updated ADA/EASD Standard of Care, 2017Slide6

Delays in Intensification of TherapySlide7

The Role of Basal Insulin and GLP-1 RA in Controlling HyperglycemiaSlide8

Intensifying Therapy With Basal Insulin and GLP-1 RASlide9

DUAL V: Key ResultsSlide10

DUAL VII: Key ResultsSlide11

LixiLan-O Trial: Study DesignSlide12

LixiLan-L Trial: Study DesignSlide13

LixiLan-O: Patients Achieving Composite EndpointsSlide14

LixiLan-L Trial: Change in HbA1c and Composite EndpointsSlide15

Simultaneous or Sequential Combination:

LixiLan-O and GetGoal DUO-1 TrialsSlide16

Simultaneous or Sequential Combination:

LixiLan-O and GetGoal DUO-1 Trials (cont)Slide17

Simultaneous or Sequential Combination:LixiLan-L and GetGoal Duo-2 TrialsSlide18

Shorter Time to Glycemic Control With IGlarLixi vs Gla-100: HbA1cSlide19

Shorter Time to Glycemic Control With IGlarLixi vs Gla-100: FPGSlide20

Shorter Time to Glycemic Control With IDegLira vs IDeg or LiraglutideSlide21

Patients Who Can Benefit Most From FRCsSlide22

LixiLan-L Subgroup AnalysesSlide23

FRC of Insulin GLP-1 RAs: Key ConsiderationsSlide24

SummarySlide25

Insulin/GLP-1 Agonist Combinations in Primary CareSlide26

Treating T2DM in Primary CareSlide27

FRCs of Basal Insulin/GLP-1 RA: Recap Slide28

The Role of FRCs in Primary CareSlide29

Which Patients Would Benefit Most in Primary Care?Slide30

OutlookSlide31

AbbreviationsSlide32

Abbreviations (cont)