Issues in Autism Evaluation: Differential Diagnosis, Special Populations, Accurate and - PowerPoint Presentation

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Issues in Autism Evaluation: Differential Diagnosis, Special Populations, Accurate and Efficient Measures

Laurie

McGarry

Klose

, Ph.D., LSSPSlide2

Objectives

Examine DSM-V diagnostic criteria for Autism Spectrum Disorders

Analyze utility of frequently used autism assessment measures in diagnostic formulation

Consider related neurological, developmental and emotional conditions

Develop strategies for differential diagnosisSlide3

DSM-IV-TR vs DSM-V

3 symptom categories

6 diagnostic items endorsed

Specifies onset prior to age 3

Includes Rhett’s, Childhood Disintegrative Disorder, Asperger’s Syndrome, PDD-NOS

2 categories

Three diagnostic items endorsed

Specifies early development

Includes parameters for designating severitySlide4

Diagnostic Criteria A

“Persistent deficits in social communication and social interaction across multiple contexts, as manifested by the following, currently or by history (examples are illustrative, not exhaustive”Slide5

“Deficits in social-emotional reciprocity, ranging, for example, from abnormal approach and failure of normal back and forth conversation; to reduced sharing of interests, emotions, or affect; to failure to initiate or respond to social interactions.”

“Deficits in nonverbal communication behaviors used for social interaction, ranging, for example, from poorly integrated verbal and nonverbal communication; to abnormalities in eye contact and body language or deficits in understanding and use of gestures; to a total lack of facial expressions and nonverbal communication“Slide6

“Deficits in developing, maintaining, and understanding relationships, ranging, for example, from difficulties adjusting behavior to suit various social contexts; to difficulties in sharing imaginative play or in making friends; to absence of interest in peers.”

“Specify current severity: Severity is based on social communication impairments and restricted , repetitive patterns of behavior.”Slide7

Diagnostic Criteria B

“Restricted, repetitive patterns of behavior, interests, or activities, as manifested by at least two of the following, currently or by history (examples are illustrative, not exhaustive; see text)”Slide8

“Stereotyped or repetitive motor movements, use of objects, or speech (e.g. simple motor stereotypies, lining up toys or flipping objects, echolalia, idiosyncratic phrases).”

“Insistence on sameness, inflexible adherence to routines, or ritualized patterns of verbal or nonverbal behavior (e.g., extreme distress at small changes, difficulties with transitions, rigid thinking patterns, greeting rituals, need to take the same route or eat same food everyday).”Slide9

“Highly restricted, fixated interests that are abnormal in intensity or focus (e.g., strong attachment to or preoccupation with unusual objects, excessively circumscribed or perseverative interests).”

“Hyper- or

hyporeactivity

to sensory input or unusual interest in

senspry

aspects of the environment (e.g., apparent indifference to pain/temperature, adverse response to specific sounds or textures, excessive smelling or touching of objects, visual fascination with lights or movement.”Slide10

Diagnostic Criteria C

“ Symptoms must be present in the early developmental period (but may not become fully manifest until social demands exceed limited capacities, or may be masked by learned strategies in later life).”Slide11

Diagnostic Criteria D

“Symptoms cause clinically significant impairment in social, occupational, or other important areas of current functioning.”Slide12

Diagnostic Criteria E

“These disturbances are not better explained by intellectual disability (intellectual developmental disorder) or global developmental delay. Intellectual disability and autism spectrum disorder frequently co-occur; to make comorbid diagnosis of autism spectrum disorder and intellectual disability, social communication should be below that expected for general developmental level.”Slide13

Concerning Individuals with a Previous Diagnosis of Autism, Asperger’s or PDD-NOS

“

Note:

Individuals with a well-established DSM-IV diagnosis of autistic disorder, Asperger’s disorder, or pervasive developmental disorder not otherwise specified should be given the diagnosis of autism spectrum disorder. Individuals who have marked deficits in social communication, but whose symptoms do not otherwise meet criteria for autism spectrum disorder, should be evaluated for social (pragmatic) communication disorder.”Slide14

Additional Specifications to be Included

With or without accompanying intellectual impairment

With or without accompanying language impairment

Associated with a known medical or genetic condition or environmental factor

Associated with another neurodevelopmental, mental, or behavioral disorder

With catatoniaSlide15

Neurodevelopmental Disorders

Intellectual Disability (Intellectual Developmental Disorder)

Global Developmental Delay

Unspecified Intellectual Disability (Intellectual Developmental Disorder)

Language Disorder

Speech Sound DisorderChildhood-Onset Fluency Disorder (Stuttering)Slide16

Neurodevelopmental Disorders, Cont.

Social (Pragmatic) Communication Disorder

Unspecified Communication Disorder

Autism Spectrum Disorder

Attention-Deficit/Hyperactivity Disorder- Combined presentation, Predominantly inattentive presentation, Predominantly hyperactive/impulsive presentation

Unspecified Attention-Deficit/Hyperactivity DisorderSlide17

Neurodevelopmental Disorders, Cont.

Specific Learning Disorder- With impairment in reading, With impairment in written expression, With impairment in mathematics

Developmental Coordination Disorder

Stereotypic Movement Disorder- With/out self-injurious behavior

Tourette’s Disorder

Persistent (Chronic) Motor or Vocal Tic DisorderSlide18

Neurodevelopmental Disorders, Cont.

Other Specified Tic Disorder

Unspecified Tic Disorder

Other Specified Neurodevelopmental Disorder

Unspecified Neurodevelopmental DisorderSlide19

Persistent deficits in social communication and social interaction across multiple contexts

Restricted, repetitive patterns of behavior, interests, or activities

Symptoms must be present in the early developmental period

Symptoms cause clinically significant impairment

Not better explained by intellectual disability

Interview/Developmental History

X

X

+

X

-

Autism Diagnostic Observation Schedule, Second Edition (ADOS-2

)

X

+

-

X

-

Autism Diagnostic Interview-Revised (ADI-R)

X

X

+

X

-

Social Responsiveness Scale, Second Edition (SRS-2)

+

-

-

X

-

Social Communication Questionnaire (SCQ)

X

-

-X-Behavior Assessment System for Children, Second Edition (BASC-2) Parent and Teacher ReportsX--X-Adaptive Behavior Assessment System, Second Edition (ABAS-II)Parent and Teacher ReportsX--+XGilliam Autism Rating Scale, Second Edition (GARS-2)Parent and Teacher ReportsXX-X-Childhood Autism Rating Scale, Second Edition (CARS2)++-XXHaak Sentence Completion Test-X-X-Projective Drawings-X-XXCognitive Assessment---X+            Slide20

Persistent deficits in social communication and social interaction across multiple contexts

Restricted, repetitive patterns of behavior, interests, or activities

Symptoms must be present in the early developmental period

Symptoms cause clinically significant impairment

Not better explained by intellectual disability

Interview/Developmental History

X

X

+

X

-

Autism Diagnostic Observation Schedule, Second Edition (ADOS-2)

X

+

-

X

-

Autism Diagnostic Interview-Revised (ADI-R)

X

X

+

X

-

Social Responsiveness Scale, Second Edition (SRS-2)

+

-

-

X

-

Social Communication Questionnaire (SCQ)

X

-

-

X

-Behavior Assessment System for Children, Second Edition (BASC-2) Parent and Teacher ReportsX--X-Adaptive Behavior Assessment System, Second Edition (ABAS-II)Parent and Teacher ReportsX--+XGilliam Autism Rating Scale, Second Edition (GARS-2)Parent and Teacher ReportsXX-X-Childhood Autism Rating Scale, Second Edition (CARS2)++-XXHaak Sentence Completion Test-X-X-Projective Drawings-X-XXCognitive Assessment---X+Slide21

ASD and ID

Differential diagnosis considerations:

Delays in social communication must be more severe than would be expected for the developmental level.

Tools:

Verbal/nonverbal ability tests, Social Responsiveness Scale-2, Social Communication Questionnaire, ADI-RSlide22

ASD and Social (Pragmatic) Communication Disorder

Impairments in social communication without the presence of repetitive, restricted or stereotyped behaviors may meet the criteria for Social Communication Disorder

When those stereotyped behaviors are present, the diagnosis of ASD supersedes Social Communication Disorder

Tools:

ADI-R, ADOS-2, SRS2, SCQ, interview, observationSlide23

ASD and ADHD

Abnormalities of attention- either overly focused or apparent lack of focus- and hyperactivity are common features in persons with ASD.

ADHD diagnosis should be made when the level of attention difficulties or hyperactivity exceed those that would be seen in individuals with similar developmental levels and similar severity levels of ASDSlide24

ASD and Affective Disorders

Comorbidity rates for ASD and affective or anxiety disorders is as high as 70%

For individuals who meet diagnostic criteria for ASD, specific symptomology should be investigated for comorbid diagnoses including changes in sleep or eating patterns, irritability, mania, including duration guidelines in diagnostic criteriaSlide25

ASD and Anxiety Disorders

Comorbidity up to 70%

When diagnostic criteria for ASD are met, attention is given to specific criteria for anxiety disorders that are distinct from ASD criteria including significant distress when separating from caregivers, excessive worry about safety of caregivers, school refusal, selective

mutism

, fear of peer rejection

Indications of anxiety not consistent with ASD- social impairments do not persist with familiar persons, age appropriate social

capacity,

but not utilized effectivelySlide26

ASD and OCD

Repetitive behavior is performed in order to reduce anxiety; intrusive recurrent thoughts inhibit functioning

If social communication deficits are present, then ASD may more appropriately account for the repetitive behavior; if not, OCD is more appropriateSlide27

Reactive Attachment Disorder and ASD

Diagnostic criteria include specific event prior to onset of symptoms including inadequate or inconsistent opportunities to form attachments with caregivers

Reactive Attachment Disorder does not include the restrictive interests, unusual sensory reactions, repetitive (but not stereotyped) behavior.

Both disorders may include stereotyped behaviors such as rocking or flapping and impaired social reciprocity.Slide28

ASD and ODD

ODD includes an element of vindictiveness

ODD includes an awareness that behavior is annoying or disruptive to others

ODD includes a pervasive sense of anger or resentfulness and emotional

dysregulation

With ASD, the noncompliant behavior results in lack of understanding the behavioral expectations for social situationsSlide29

ASD and Intermittent Explosive Disorder

Aggression with physical damage or injury: 3 incidents in last 12 months; Aggressive episodes without physical damage or injury: 2X per week for 3 months.

No precursors identifiable and not used for manipulation

Magnitude exceeds that expected with ASDSlide30

ASD and Conduct Disorder

Conduct disorder involves the purposeful violation of social rules or violation of the rights of others

Antisocial behavior is proactive, predatory and purposeful

ASD related rule breaking behavior results from not understanding social rules or not possessing the skills to negotiate social rulesSlide31

ASD and Schizoid Personality Disorder

Flat affect and restricted range of emotions contribute to lack of social interactions

No interest in social relationships- a rejection rather than a lack of understanding or need for social interactions

Includes a distinct lack of pleasure in few, if any, activities

Very similar outward presentation between mild ASD and Schizoid- repetitive behavior and restricted interests are key

differentila

diagnosis featuresSlide32

Process for Making Differential and Comorbid Diagnoses