PPT-Thalassemia Standards of Care

Ellis J Neufeld MD PhD Egan Family Foundation Chair in Transitional Medicine Harvard Medical School Associate Chief DanaFarber Boston Childrens Center for Cancer and Blood Disorders Chair Medical Advisory Board CAF. Fahd . Alareashi. .. . Anemia…. What is Anemia?. A condition characterized by a decrease in RBCs mass, hemoglobin or RBCs count.. Adult male: . Hb. .  13 g/. dL. , or . Hct. .: 41%.. Adult Females: . Ashutosh Lal, MD. Northern California Thalassemia Center. UCSF Benioff Children’s Hospital Oakland. Thalassemia Syndromes: . Many diagnoses. Oakland Data (n=203). What is the proportion of . non-transfusion-dependent thalassemia. Dr. Anita Nadkarni , Deputy Director. National Institute of Immunohematology (ICMR) Mumbai. INDIA. 3. rd. International Conference on . Hematology & Blood Disorders . November 02-04, 2015 Atlanta, USA. .. . Anemia…. What is Anemia?. A condition characterized by a decrease in RBCs mass, hemoglobin or RBCs count.. Adult male: . Hb. .  13 g/. dL. , or . Hct. .: 41%.. Adult Females: . Hb.  12 g/. Thalassemia. Prof. Firoza Begum. High Risk Pregnancy & Infertility Specialist. Chairman, Fetomaternal Medicine . Dept. , BSMMU. Introduction. Hemoglobinopathies. are among the most common inherited diseases.. BY A COMPUTATIONAL METHOD. Yulia Einav. Holon Institute of Technology. Israel. Outline. Introduction. Sys. tem. desi. g. n. Results. Summary & Conclusions. Acknowledgements. α and β thalassemia are the most common . Thalassemia. Beta-thalassaemia is a global disease - most prevalent in South Asia, the Far East, the Middle East, and Mediterranean countries. . Distribution is attributed largely to natural selection of heterozygote carriers because of protection against falciparum malaria. . MD; FRCP (London); . FRCPEdin. ; . FRCSEdin. T. halassemia. Hemoglobin molecule. : is the iron-containing oxygen-transport . metalloprotein. in the red blood cells of all vertebrates.. The normal . haemoglobin. Learning Objectives. ▪ . Hemoglobinopathies. (Abnormal . Hb. . variants). ▪. Different . Hemoglobin . combinations-. Nr. and . Abn. •. Sickle . cell trait is the . heterozygous form . of the . : are genetic(AR) disorders in . globin. chain production. . In individuals with β. -thalassemia. , there is either: . complete. absence of β-globin gene production . (β. 0. -thalassemia). Kakavoulis. . Nikolaos. Patras Ioannis. What is . Thalassaemia. ?. . Thalassaemia. is a group of inherited disorders of hemoglobin synthesis characterized by . reduced . or . absen. ce. . of one . DEFINITION: . Thalassemia is blood disorder passed down through families (inherited) in which the body makes an abnormal form or inadequate amount of . haemoglobin. .. CAUSE:. . Haemoglobin. made of 2 proteins: . Newborn Screening ACT Sheet Beta Thalassemia Major(Hemoglobin F [Fetal] Only) Contact the family to inform them of the screening result.Evaluate infant, assess for splenomegaly, and do complete blood To the Editor,Coinheritance of hereditary spherocytosis ,HS) thalassemia is very rare. HS is a familial haemolytic disorder resulting from primary abnormality of red cell membrane. It is transmitted